Product Name
5-hydroxytryptamine receptor 3A (Htr3a), Recombinant Protein
Full Product Name
Recombinant Mouse 5-hydroxytryptamine receptor 3A (Htr3a)
Product Gene Name
Htr3a recombinant protein
[Similar Products]
Product Synonym Gene Name
5ht3; Htr3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
24-487aa; Full length protein
Sequence
SRRRATQEDT TQPALLRLSD HLLANYKKGV RPVRDWRKPT TVSIDVIMYA ILNVDEKNQV LTTYIWYRQY WTDEFLQWTP EDFDNVTKLS IPTDSIWVPD ILINEFVDVG KSPNIPYVYV HHRGEVQNYK PLQLVTACSL DIYNFPFDVQ NCSLTFTSWL HTIQDINITL WRSPEEVRSD KSIFINQGEW ELLEVFPQFK EFSIDISNSY AEMKFYVIIR RRPLFYAVSL LLPSIFLMVV DIVGFCLPPD SGERVSFKIT LLLGYSVFLI IVSDTLPATI GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQRPVP DWLRHLVLDR IAWILCLGEQ PMAHRPPATF QANKTDDCSG SDLLPAMGNH CSHVGGPQDL EKTPRGRGSP LPPPREASLA VRGLLQELSS IRHFLEKRDE MREVARDWLR VGYVLDRLLF RIYLLAVLAY SITLVTLWSI WHYS
3D Structure
ModBase 3D Structure for P23979
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Htr3a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Htr3a recombinant protein
Transmembrane Protein
Application Notes for Htr3a recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for Htr3a. It may not necessarily be applicable to this product.
NCBI Accession #
NP_038589.2
[Other Products]
NCBI GenBank Nucleotide #
NM_013561.2
[Other Products]
UniProt Primary Accession #
P23979
[Other Products]
UniProt Secondary Accession #
Q61225; Q61226[Other Products]
UniProt Related Accession #
P23979[Other Products]
Molecular Weight
55,474 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 3A isoform 1
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 3A
NCBI Official Symbol
Htr3a??[Similar Products]
NCBI Official Synonym Symbols
5-HT3
??[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 3A
UniProt Protein Name
5-hydroxytryptamine receptor 3A
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
Htr3a??[Similar Products]
UniProt Synonym Gene Names
5ht3; Htr3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R??[Similar Products]
UniProt Entry Name
5HT3A_MOUSE
UniProt Comments for Htr3a
5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral; Transporter, ion channel; Channel, ligand-gated
Cellular Component: axon; cell junction; cell soma; cytoplasm; integral to membrane; membrane; plasma membrane; postsynaptic membrane; synapse
Molecular Function: acetylcholine receptor activity; extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; nicotinic acetylcholine-activated cation-selective channel activity; serotonin binding; serotonin-activated cation-selective channel activity; serotonin-gated cation channel activity; voltage-gated potassium channel activity
Biological Process: ion transport; serotonin receptor signaling pathway; transport
Research Articles on Htr3a
1. The deletion of Htr3a was related to fatal arrhythmias and sudden cardiac death during pregnancy, and its activation reversed the QT prolongation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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