5-hydroxytryptamine receptor 3A; 5-HT3-A; 5-HT3A; 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor; HTR3A; 5HT3R; HTR3

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This HTR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-58 amino acids from the N-terminal region of human HTR3A.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-HTR3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The product of this gene belongs to the ligand-gated ion
channel receptor superfamily. This gene encodes subunit A of the
type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic
hormone that functions as a neurotransmitter, a hormone, and a
mitogen. This receptor causes fast, depolarizing responses in
neurons after activation. It appears that the heteromeric
combination of A and B subunits is necessary to provide the full
functional features of this receptor, since either subunit alone
results in receptors with very low conductance and response
amplitude. Alternatively spliced transcript variants encoding
different isoforms have been identified.

Metabolism; Neuroscience

Western Blot (WB), ELISA (EIA)

WB~~1:1000

HTR3A Antibody (N-term) western blot analysis in MDA-MB453,K562 cell line lysates (35ug/lane).This demonstrates the HTR3A antibody detected the HTR3A protein (arrow).

55280

5-hydroxytryptamine (serotonin) receptor 3A, ionotropic

5-hydroxytryptamine receptor 3A

5-hydroxytryptamine receptor 3A

5HT3R; HTR3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R??[Similar Products]

5HT3A_HUMAN

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Channel, cation; Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: postsynaptic membrane; cell soma; integral to plasma membrane; axon; cytoplasm; plasma membrane; cell junction

Molecular Function: serotonin-activated cation-selective channel activity; voltage-gated potassium channel activity; serotonin binding; serotonin receptor activity; receptor activity

Biological Process: synaptic transmission; response to ethanol; transport; digestion; response to cocaine; transmembrane transport; serotonin receptor signaling pathway

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Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010)
Hammer, C., et al. Pharmacogenomics 11(7):943-950(2010)

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