Full Product Name
HTR3A, NT (HTR3A, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine receptor 3, Serotonin receptor 3A, Serotonin-gated ion channel receptor)
Product Synonym Names
Anti -HTR3A, NT (HTR3A, 5HT3R, HTR3, 5-hydroxytryptamine receptor 3A, 5-hydroxytryptamine receptor 3, Serotonin receptor 3A, Serotonin-gated ion channel receptor)
Product Gene Name
anti-Htr3a antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 9; NC_000075.6 (48899213..48911099, complement). Location: 9 A5.3; 9
3D Structure
ModBase 3D Structure for P23979
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
HTR3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human HTR3A.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-Htr3a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-Htr3a antibody
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified.
Product Categories/Family for anti-Htr3a antibody
Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-Htr3a antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-Htr3a antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for Htr3a. It may not necessarily be applicable to this product.
NCBI Accession #
AAI45744.1
[Other Products]
UniProt Primary Accession #
P23979
[Other Products]
UniProt Secondary Accession #
Q61225; Q61226[Other Products]
UniProt Related Accession #
P23979[Other Products]
Molecular Weight
56,056 Da[Similar Products]
NCBI Official Full Name
Htr3a protein
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 3A
NCBI Official Symbol
Htr3a??[Similar Products]
NCBI Official Synonym Symbols
5-HT3
??[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 3A; 5-HT-3; 5-HT3A; 5-HT3R; 5-HT3-A; serotonin receptor 3A; 5HT3 serotonin receptor; serotonin-gated ion channel receptor
UniProt Protein Name
5-hydroxytryptamine receptor 3A
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
Htr3a??[Similar Products]
UniProt Synonym Gene Names
5ht3; Htr3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R??[Similar Products]
UniProt Entry Name
5HT3A_MOUSE
UniProt Comments for Htr3a
5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, ion channel; Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral; Channel, cation
Cellular Component: postsynaptic membrane; cell soma; membrane; axon; cytoplasm; integral to membrane; plasma membrane; synapse; cell junction
Molecular Function: voltage-gated potassium channel activity; serotonin-activated cation-selective channel activity; serotonin binding; serotonin receptor activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity
Biological Process: transport; ion transport; serotonin receptor signaling pathway; cation transport
Research Articles on Htr3a
1. Serotonin 5-HT3 receptors control morphological maturation of Purkinje cells via reelin
Precautions
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Disclaimer
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