Full Product Name
Anti-Musk (Muscle-specific kinase receptor)- (C-terminal) Antibody
Product Gene Name
anti-MUSK antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Mouse, Rat
Purity/Purification
Purified by antigen-specific affinity chromatography.
Concentration
1ug/ul (lot specific)
Immunogen
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of mouse Musk (Muscle-specific kinase receptor)
Storage Buffer
PBS, pH 7.4 with 0.05% sodium azide.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-MUSK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MUSK antibody
The Musk (Muscle-specific kinase receptor) is a receptor tyrosine kinase that is a key mediator of agrin's action and is involved in neuromuscular junction (NMJ) organization. Musk belongs to the Tyr protein kinase family.
Applications Tested/Suitable for anti-MUSK antibody
Western Blot (WB), ELISA (EIA)
NCBI/Uniprot data below describe general gene information for MUSK. It may not necessarily be applicable to this product.
NCBI Accession #
AAI09100.1
[Other Products]
UniProt Secondary Accession #
Q32MJ8; Q32MJ9; Q5VZW7; Q5VZW8[Other Products]
UniProt Related Accession #
O15146[Other Products]
Molecular Weight
86,425 Da
NCBI Official Full Name
MUSK protein
NCBI Official Synonym Full Names
muscle associated receptor tyrosine kinase
NCBI Official Symbol
MUSK??[Similar Products]
NCBI Official Synonym Symbols
CMS9; FADS
??[Similar Products]
NCBI Protein Information
muscle, skeletal receptor tyrosine-protein kinase
UniProt Protein Name
Muscle, skeletal receptor tyrosine-protein kinase
UniProt Synonym Protein Names
Muscle-specific tyrosine-protein kinase receptor; MuSK; Muscle-specific kinase receptor
UniProt Gene Name
MUSK??[Similar Products]
UniProt Synonym Gene Names
MuSK; Muscle-specific kinase receptor??[Similar Products]
NCBI Summary for MUSK
This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]
UniProt Comments for MUSK
MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Musk family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 9q31.3
Cellular Component: integral to plasma membrane; neuromuscular junction; postsynaptic membrane; receptor complex
Molecular Function: protein binding; protein-tyrosine kinase activity
Biological Process: memory; neuromuscular junction development; positive regulation of protein amino acid phosphorylation; protein amino acid autophosphorylation; regulation of synaptic growth at neuromuscular junction; transmembrane receptor protein tyrosine kinase signaling pathway
Disease: Fetal Akinesia Deformation Sequence; Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency
Product References and Citations for anti-MUSK antibody
Ganju, P., et al, Oncogene 11 (2), 281-290 (1995) Okada, K., et al, Science 312 (5781), 1802-1805 (2006) Kumar, P., et al, Biochem. Biophys. Res. Commun. 342 (2),522-528 (2006) Shigemoto, K., et al, J. Clin. Invest. 116 (4), 1016-1024 (2006) Hesser, B.A., et al, Mol. Cell. Neurosci. 31 (3), 470-480 (2006) Jaworski, A., et al, J. Neurosci. 26 (2), 655-661 (2006) Kuehn, R., et al, Gene 360 (2), 83-91 (2005) Strochlic, L., et al, Bioessays 27 (11), 1129-1135 (2005) Kim, C.H., et al, Mol. Cell. Biol. 25 (13),5329-5338 (2005) Srivastava, A.K., et al, J. Bone Miner. Res. 20 (6), 1041-1050 (2005)
Research Articles on MUSK
1. Classical electromyography revealed the presence of myopathic changes more frequently in MuSK myasthenia gravis compared to acetylcholine receptor myasthenia gravis
Precautions
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Disclaimer
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