Human Keratin; type II cytoskeletal 74 (KRT74) ELISA kit; K6IRS4; KRT5C; KRT6IRS4; keratin 5c; keratin 6 irs4; keratin; type II cytoskeletal 74; keratin 74

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of KRT74 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9316654 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the keratin 74 (KRT74) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KRT74. The ELISA analytical biochemical technique of the MBS9316654 kit is based on KRT74 antibody-KRT74 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KRT74 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KRT74. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

57,865 Da

keratin 74

keratin, type II cytoskeletal 74; K5C; K74; CK-74; keratin 5c; keratin-5c; keratin-74; cytokeratin-74; keratin 6 irs4; type-II keratin Kb37; type II inner root sheath-specific keratin-K6irs4

Keratin, type II cytoskeletal 74

K6IRS4; KB37; KRT5C; KRT6IRS4; CK-74; K5C; K74??[Similar Products]

K2C74_HUMAN

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009]

KRT74: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable). Defects in KRT74 are a cause of woolly hair autosomal dominant (ADWH). A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Defects in KRT74 are the cause of hypotrichosis type 3 (HYPT3). A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. Belongs to the intermediate filament family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: keratin filament; cytoplasm

Molecular Function: structural molecule activity

Biological Process: intermediate filament cytoskeleton organization and biogenesis

Disease: Ectodermal Dysplasia 7, Hair/nail Type; Woolly Hair, Autosomal Dominant; Hypotrichosis 3

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