Full Product Name
LAL Antibody
Product Synonym Names
Acid cholesteryl ester hydrolase; CESD; cholesterol ester hydrolase; cholesterol ester storage disease; Cholesteryl esterase; Hydrolase deficiency; LAL; LAL deficiency cholesterol ester; LICH_HUMAN; lipA; LIPA deficiency; Lipase A; lipase A, lysosomal acid, cholesterol esterase; lysosomal acid lipase; lysosomal acid lipase deficiency; Lysosomal acid lipase/cholesteryl ester hydrolase; Sterol esterase
Product Gene Name
anti-LAL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P38571
Specificity
LAL antibody detects endogenous levels of total LAL
Purity/Purification
Affinity-Chromatography
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
Purified recombinant fragment of human LAL expressed in E. Coli
Subcellular Location
Lysosome.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-LAL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LAL antibody
Description: Lysosomal acid lipase (LAL), with 378-amino acid protein(43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates.
Function: Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Similarity: Belongs to the AB hydrolase superfamily. Lipase family.
Applications Tested/Suitable for anti-LAL antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-LAL antibody
ELISA: 1:10000
WB: 1:500-1:2000
Western Blot (WB) of anti-LAL antibody
Figure 1: Western blot analysis using LAL mouse mAb against LAL recombinant protein.
NCBI/Uniprot data below describe general gene information for LAL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000226.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000235.3
[Other Products]
UniProt Primary Accession #
P38571
[Other Products]
UniProt Secondary Accession #
Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0; B2RBH5; D3DR29[Other Products]
UniProt Related Accession #
P38571[Other Products]
Molecular Weight
Observed: 46 kDa
Predicted: 46 kDa
NCBI Official Full Name
lysosomal acid lipase/cholesteryl ester hydrolase isoform 1
NCBI Official Synonym Full Names
lipase A, lysosomal acid type
NCBI Official Symbol
LIPA??[Similar Products]
NCBI Official Synonym Symbols
LAL; CESD
??[Similar Products]
NCBI Protein Information
lysosomal acid lipase/cholesteryl ester hydrolase
UniProt Protein Name
Lysosomal acid lipase/cholesteryl ester hydrolase
UniProt Synonym Protein Names
Cholesteryl esterase; Lipase A; Sterol esterase
UniProt Gene Name
LIPA??[Similar Products]
UniProt Synonym Gene Names
Acid cholesteryl ester hydrolase; LAL??[Similar Products]
NCBI Summary for LAL
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
UniProt Comments for LAL
Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Research Articles on LAL
1. Report LIPA variants/phenotype in childhood-onset lysosomal acid lipase deficiency.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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