Product Name
LAL (LIPA), Polyclonal Antibody
Full Product Name
Anti-LAL Antibody
Product Synonym Names
Lysosomal acid lipase/cholesteryl ester hydrolase; Acid cholesteryl ester hydrolase; LAL; Cholesteryl esterase; Lipase A; Sterol esterase
Product Gene Name
anti-LIPA antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P38571
Specificity
Recognizes endogenous levels of LAL protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human LAL
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-LIPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LIPA antibody
Rabbit polyclonal antibody to LAL
Applications Tested/Suitable for anti-LIPA antibody
Western Blot (WB)
Application Notes for anti-LIPA antibody
WB: 1/500 - 1/2000
Western Blot (WB) of anti-LIPA antibody
Western blot analysis of LAL expression in Hela (A) whole cell lysates.

NCBI/Uniprot data below describe general gene information for LIPA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000226.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000235.3
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UniProt Primary Accession #
P38571
[Other Products]
UniProt Secondary Accession #
Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0; B2RBH5; D3DR29[Other Products]
UniProt Related Accession #
P38571[Other Products]
Molecular Weight
39,112 Da
NCBI Official Full Name
lysosomal acid lipase/cholesteryl ester hydrolase isoform 1
NCBI Official Synonym Full Names
lipase A, lysosomal acid type
NCBI Official Symbol
LIPA??[Similar Products]
NCBI Official Synonym Symbols
LAL; CESD
??[Similar Products]
NCBI Protein Information
lysosomal acid lipase/cholesteryl ester hydrolase
UniProt Protein Name
Lysosomal acid lipase/cholesteryl ester hydrolase
UniProt Synonym Protein Names
Cholesteryl esterase; Lipase A; Sterol esterase
Protein Family
Lipoprotein
UniProt Gene Name
LIPA??[Similar Products]
UniProt Synonym Gene Names
Acid cholesteryl ester hydrolase; LAL??[Similar Products]
UniProt Entry Name
LICH_HUMAN
NCBI Summary for LIPA
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
UniProt Comments for LIPA
LIPA: Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor- mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. Defects in LIPA are the cause of Wolman disease (WOD). WOD is a severe manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. WOD occurs in infancy and is nearly always fatal before the age of 1 year. Defects in LIPA are the cause of cholesteryl ester storage disease (CESD). CESD is a mild manifestation of LIPA deficiency, leading to the accumulation of cholesteryl esters and triglycerides in most tissues of the body. It is characterized by late-onset. Belongs to the AB hydrolase superfamily. Lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - steroid biosynthesis; Hydrolase; EC 3.1.1.13
Chromosomal Location of Human Ortholog: 10q23.2-q23.3
Cellular Component: lysosome
Molecular Function: lipase activity; sterol esterase activity
Biological Process: cell morphogenesis; cell proliferation; cytokine production; fatty acid metabolic process; homeostasis of number of cells within a tissue; inflammatory response; lipid catabolic process; lung development; sterol metabolic process; tissue remodeling
Disease: Lysosomal Acid Lipase Deficiency
Research Articles on LIPA
1. lysosomal acid lipase in hepatocytes is a critical metabolic enzyme in controlling neutral lipid metabolism
Precautions
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