Full Product Name
LAL Antibody
Product Synonym Names
LAL; CESD; LIPA
Product Gene Name
anti-LAL antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P38571
Clone Number
9G7F12; 7G6D7
Form/Format
Purified antibody in PBS containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of LAL expressed in E. Coli.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C
Other Notes
Small volumes of anti-LAL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-LAL antibody
Lysosomal acid lipase (LAL), with 378-amino acid protein(43-54 kDa), functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides which are taken up by receptor-mediated endocytosis. An inherited deficiency or low activity of human lysosomal acid lipase results in the intralysosomal storage of the respective lipid substrates. So it is also responsible for the rare conditions of Wolman disease and cholesteryl ester storage disease (CESD). As the enzyme is synthesized by all nucleated cells, lipid-laden cells are found in all organs, particularly in liver, spleen, the adrenal and the hemopoietic system, and in the intestine as well as in the lymph nodes, lungs, testes, and ovaries.
Product Categories/Family for anti-LAL antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-LAL antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-LAL antibody
WB: 1:500-1:2000
ELISA: 1:10000
Western Blot (WB) of anti-LAL antibody
Figure 1. Western blot analysis using LAL mouse mAb against LAL recombinant protein.
NCBI/Uniprot data below describe general gene information for LAL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000226.2
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NCBI GenBank Nucleotide #
NM_000235.3
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UniProt Primary Accession #
P38571
[Other Products]
UniProt Secondary Accession #
Q16529; Q53H21; Q5T074; Q5T771; Q96EJ0; B2RBH5; D3DR29[Other Products]
UniProt Related Accession #
P38571[Other Products]
Molecular Weight
39,112 Da
NCBI Official Full Name
lysosomal acid lipase/cholesteryl ester hydrolase isoform 1
NCBI Official Synonym Full Names
lipase A, lysosomal acid type
NCBI Official Symbol
LIPA??[Similar Products]
NCBI Official Synonym Symbols
LAL; CESD
??[Similar Products]
NCBI Protein Information
lysosomal acid lipase/cholesteryl ester hydrolase
UniProt Protein Name
Lysosomal acid lipase/cholesteryl ester hydrolase
UniProt Synonym Protein Names
Cholesteryl esterase; Lipase A; Sterol esterase
UniProt Gene Name
LIPA??[Similar Products]
UniProt Synonym Gene Names
Acid cholesteryl ester hydrolase; LAL??[Similar Products]
NCBI Summary for LAL
This gene encodes lipase A, the lysosomal acid lipase (also known as cholesterol ester hydrolase). This enzyme functions in the lysosome to catalyze the hydrolysis of cholesteryl esters and triglycerides. Mutations in this gene can result in Wolman disease and cholesteryl ester storage disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
UniProt Comments for LAL
Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation.
Research Articles on LAL
1. LAL activity is significantly reduced in NAFLD, compared to that in HCV patients. This finding is particularly evident in the pre-cirrhotic stage of disease. LAL activity is also correlated with platelet and white blood cell count, suggesting an analytic interference of portal-hypertension-induced pancytopenia on DBS-determined LAL activity.
Precautions
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Disclaimer
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