BRCA2 (pSer3291) [P-CS-4]; BRCA 2 antibody; BRCA1/BRCA2 containing complex subunit 2 antibody; Brca2 antibody; BRCA2_HUMAN antibody; BRCC 2 antibody; BRCC2 antibody; Breast and ovarian cancer susceptibility gene early onset antibody; Breast cancer 2 early onset antibody; Breast Cancer 2 tumor suppressor antibody; Breast cancer susceptibility protein BRCA2 antibody; Breast cancer type 2 susceptibility protein antibody; BROVCA2 antibody; FACD antibody; FAD 1 antibody; FAD antibody; FAD1 antibody; FANCB antibody; FANCD 1 antibody; FANCD antibody; FANCD1 antibody; Fanconi anemia complementation group D1 antibod; Fanconi anemia group D1 protein antibody; GLM3 antibody; OTTHUMP00000018803 antibody; OTTHUMP00000042401 antibody

For Research Use Only. Not for use in diagnostic procedures.

Rabbit

Phosphorylated BRCA2 (pSer3291)

Peptide Affinity Chromatography

Purified antibody containing PBS + 0.09% sodium azide

0.36mg/ml (lot specific)

Small volumes of anti-BRCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.

Western Blot (WB), ELISA (EIA)

Western Blot: As a guideline start at 1ug/ml.

384,202 Da

breast cancer 2

breast cancer type 2 susceptibility protein

Breast cancer type 2 susceptibility protein

FACD; FANCD1??[Similar Products]

BRCA2_HUMAN

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

BRCA2: involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation. Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoint functions. Interacts with WDR16. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer and may underlie susceptibility to uveal melanoma.

Protein type: DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: BRCA2-MAGE-D1 complex; centrosome; cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus; protein complex; secretory granule

Molecular Function: gamma-tubulin binding; H3 histone acetyltransferase activity; H4 histone acetyltransferase activity; histone acetyltransferase activity; protease binding; protein binding; single-stranded DNA binding

Biological Process: brain development; cell aging; centrosome duplication; chromosome breakage; cytokinesis; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA synthesis during DNA repair; double-strand break repair; double-strand break repair via homologous recombination; female gonad development; hemopoiesis; homologous chromosome orientation during meiosis; inner cell mass cell proliferation; male meiosis I; mammary gland development; multicellular organism growth; negative regulation of mammary gland epithelial cell proliferation; nucleotide-excision repair; oocyte maturation; positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-dependent; regulation of cytokinesis; replication fork protection; response to estradiol stimulus; response to gamma radiation; response to nutrient; response to UV-C; response to X-ray; spermatogenesis; strand displacement; telomere maintenance via recombination

Disease: Breast Cancer; Breast-ovarian Cancer, Familial, Susceptibility To, 2; Fanconi Anemia, Complementation Group D1; Glioma Susceptibility 3; Medulloblastoma; Pancreatic Cancer, Susceptibility To, 2; Prostate Cancer; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Wilms Tumor 1

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