Full Product Name
Mouse Brca2 Polyclonal Antibody
Product Synonym Names
Fancd1; Fanconi anemia group D1 protein homolog
Product Gene Name
anti-BRCA2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Rat, Mouse
Purity/Purification
Immunogen Affinity Purified
Form/Format
Liquid; 0.1MxPBS, 50% Glycerol, pH7.5
Concentration
200 ug/ml (lot specific)
Immunogen
Recombinant Human Brca2 Protein
Preparation and Storage
Store at 4 degree C for frequent use. Store at -20 degree C to -70 degree C for 6 months.
Other Notes
Small volumes of anti-BRCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-BRCA2 antibody
Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for BRCA2. It may not necessarily be applicable to this product.
UniProt Related Accession #
P51587[Other Products]
NCBI Official Full Name
BRCA2
NCBI Official Synonym Full Names
BRCA2 DNA repair associated
NCBI Official Symbol
BRCA2??[Similar Products]
NCBI Official Synonym Symbols
FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; XRCC11; BROVCA2
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NCBI Protein Information
breast cancer type 2 susceptibility protein
Protein Family
BRCA2 and CDKN1A-interacting protein
NCBI Summary for BRCA2
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
Research Articles on BRCA2
1. Assessment of the clinical relevance of BRCA2 missense variants by functional and computational approaches has been presented.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
