For Research Use Only. Not for use in diagnostic procedures.

Lyophilized powder

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Small volumes of Accn2 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Accn2 is a cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. It also permeable for Ca2+, Li+ and K+. It generates a biphasic current with a fast inactivating and a slow sustained phase and mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Accn2 functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. It modulates activity in the circuits underlying innate fear.

Peptide

Western Blot (WB)

60kDa

acid-sensing (proton-gated) ion channel 1

acid-sensing ion channel 1

Acid-sensing ion channel 1

Accn2; Asic; Bnac2; ASIC1; BNaC2??[Similar Products]

ASIC1_MOUSE

ASIC1: non-voltage-gated amiloride-sensitive cation channel permeable for sodium, potassium and lithium. A member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Expressed in most if not all brain neurons.

Protein type: Transporter; Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, cation

Cellular Component: cell surface; membrane; integral to plasma membrane; dendritic spine; integral to membrane; plasma membrane; synapse; dendritic shaft

Molecular Function: amiloride-sensitive sodium channel activity; monovalent inorganic cation transmembrane transporter activity; protein binding; ion gated channel activity; ion channel activity; cation channel activity; sodium channel activity

Biological Process: regulation of membrane potential; transport; calcium ion transport; sodium ion transport; monovalent inorganic cation transport; ion transport; sensory perception of sour taste; response to acidity; cation transport; associative learning; memory; negative regulation of neurotransmitter secretion

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