Product Name
Acid-sensing ion channel 1 (Asic1), Recombinant Protein
Full Product Name
Recombinant Rat Acid-sensing ion channel 1 (Asic1), partial
Product Gene Name
Asic1 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
70-425
Sequence
CYHHVTKLDE VAASQLTFPA VTLCNLNEFR FSQVSKNDLY HAGELLALLN NRYEIPDTQM ADEKQLEILQ DKANFRSFKP KPFNMREFYD RAGHDIRDML LSCHFRGEAC SAEDFKVVFT RYGKCYTFNS GQDGRPRLKT MKGGTGNGLE IMLDIQQDEY LPVWGETDET SFEAGIKVQI HSQDEPPFID QLGFGVAPGF QTFVSCQEQR LIYLPSPWGT CNAVTMDSDF FDSYSITACR IDCETRYLVE NCNCRMVHMP GDAPYCTPEQ YKECADPALD FLVEKDQEYC VCEMPCNLTR YGKELSMVKI PSKASAKYLA KKFNKSEQYI GENILVLDIF FEVLNYETIE QKKAYE
3D Structure
ModBase 3D Structure for P55926
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Asic1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Asic1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_077068.1
[Other Products]
NCBI GenBank Nucleotide #
NM_024154.2
[Other Products]
UniProt Primary Accession #
P55926
[Other Products]
UniProt Secondary Accession #
O88762; Q91YB8; Q99NA1[Other Products]
UniProt Related Accession #
P55926[Other Products]
Molecular Weight
62,217 Da
NCBI Official Full Name
acid-sensing ion channel 1
NCBI Official Synonym Full Names
acid sensing ion channel subunit 1
NCBI Official Symbol
Asic1??[Similar Products]
NCBI Official Synonym Symbols
Accn2
??[Similar Products]
NCBI Protein Information
acid-sensing ion channel 1
UniProt Protein Name
Acid-sensing ion channel 1
UniProt Synonym Protein Names
Amiloride-sensitive cation channel 2, neuronal; Brain sodium channel 2; BNaC2
Protein Family
Acid-sensing ion channel
UniProt Gene Name
Asic1??[Similar Products]
UniProt Synonym Gene Names
Accn2; Bnac2; BNaC2??[Similar Products]
NCBI Summary for Asic1
forms a proton-gated ion channel that may play a role in sensory neuron function and pain perception [RGD, Feb 2006]
UniProt Comments for Asic1
Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca2+ while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties.
Research Articles on Asic1
1. ASICs may enhance susceptibility to epileptogenesis in the piriform cortex.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
