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CD49d, Monoclonal Antibody

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CD49d, Monoclonal Antibody


CD49d, Monoclonal Antibody  的詳細(xì)介紹
Product Name

CD49d, Monoclonal Antibody

Full Product Name

Anti-Human CD49d Monoclonal Antibody (Biotin Conjugated)

Product Synonym Names
Human CD49d; Integrin alpha-4; ITGA4; CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD49d
Product Gene Name

anti-CD49d antibody

[Similar Products]
Matching Pairs
Antibody: CD49d Clone #BU49 (MBS2553814)
Isotype Control: IgG1, kappa Clone #MOPC-21 (MBS2557745)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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3D Structure
ModBase 3D Structure for P13612
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BU49
Host
Mouse
Species Reactivity
Human
Form/Format
Liquid; PBS with 0.05% Proclin300, 1% BSA
Conjugation
Biotin
Cellular Localization
Membrane
Preparation and Storage
Store at 2-8 degree C. Protected from prolonged exposure to light.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-CD49d antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
anti-CD49d antibody
CD49d is a 150 kD alpha integrin chain known as alpha4 integrin or VLA-4 alpha chain. It forms a heterodimer with either integrin beta1 (alpha4beta1, VLA-4) or beta7 (alpha4beta7). CD49d is expressed broadly on T lymphocytes, B lymphocytes, monocytes, thymocytes, eosinophils, basophils, mast cells, NK cells, dendritic cells, and some non-hematopoietic cells, but not on normal red blood cells, platelets or neutrophils. VLA-4 binds to VCAM-1 (CD106) and fibronectin. alpha4beta7 is the receptor for VCAM-1 and MAdCAM-1. CD49d participates in mononuclear cell trafficking to endothelial sites of inflammation and has roles in cell-cell interactions and cell adhesion to extracellular matrices. CD49d is involved in lymphocyte migration, T cell activation, and hematopoietic stem cell differentiation. CD49d is a marker to isolate pure populations of Treg cells due to its absence on Foxp3+ cells.
Applications Tested/Suitable for anti-CD49d antibody
Flow Cytometry (FC/FACS)
Application Notes for anti-CD49d antibody
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is <=1.0 ug per 10e6 cells in 100 ul volume or 100 ul of whole blood.
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NCBI/Uniprot data below describe general gene information for CD49d. It may not necessarily be applicable to this product.
NCBI GI #
67191027
NCBI GeneID
3676
NCBI Accession #
NP_000876.3 [Other Products]
NCBI GenBank Nucleotide #
NM_000885.6 [Other Products]
UniProt Primary Accession #
P13612 [Other Products]
UniProt Secondary Accession #
Q7Z4L6; D3DPG4[Other Products]
UniProt Related Accession #
P13612[Other Products]
Molecular Weight
21,536 Da
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NCBI Official Full Name
integrin alpha-4 isoform 1 preproprotein
NCBI Official Synonym Full Names
integrin subunit alpha 4
NCBI Official Symbol
ITGA4??[Similar Products]
NCBI Official Synonym Symbols
IA4; CD49D
??[Similar Products]
NCBI Protein Information
integrin alpha-4
UniProt Protein Name
Integrin alpha-4
UniProt Synonym Protein Names
CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen: CD49d
UniProt Gene Name
ITGA4??[Similar Products]
UniProt Synonym Gene Names
CD49D??[Similar Products]
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NCBI Summary for CD49d
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
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UniProt Comments for CD49d
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand- (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
Product References and Citations for anti-CD49d antibody
1. Elices M, Ed.1995. Springer Semin. Immunopathol. 16(4). 2. Lobb RR and Helmer ME. et al. 1994. J. Clin. Invest. 94:1722.

Research Articles on CD49d
1. study suggests a novel association of ITGA4 +3061A/G polymorphism with AD and its possible contribution to the disease pathology.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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