For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Antigen-specific affinity chromatography followed by Protein A affinity chromatography

Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.

1mg/ml (lot specific)

Storage: Avoid repeated freeze/thaw cycles.
Store at 4oC for frequent use.
Aliquot and store at -20oC for 12 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.

Small volumes of anti-BRCA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

WB; IHC; ICC; IP.

Western blotting: 0.5-2 ug/mL;1:500-2000
Immunohistochemistry: 5-20 ug/mL;1:50-200
Immunocytochemistry: 5-20 ug/mL;1:50-200

Optimal working dilutions must be determined by end user.

Western Blot: Sample: Recombinant protein.

DAB staining on fromalin fixed paraffin-embedded testis tissue)

DAB staining on IHC-P; Samples: Mouse Kidney Tissue)

breast cancer 2, early onset

breast cancer type 2 susceptibility protein homolog

Breast cancer type 2 susceptibility protein homolog

Fancd1??[Similar Products]

BRCA2: involved in double-strand break repair and/or homologous recombination. May participate in S phase checkpoint activation. Interacts with RAD51 and DSS1. Interacts with ubiquitinated FANCD2. Interacts with PALB2, enables the recombinational repair and checkpoint functions. Interacts with WDR16. Defects in BRCA2 are a cause of genetic susceptibility to breast cancer and may underlie susceptibility to uveal melanoma.

Protein type: DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 5 G3|5 89.52 cM

Cellular Component: BRCA2-MAGE-D1 complex; centrosome; cytoplasm; cytoskeleton; cytosol; lateral element; nuclear chromosome, telomeric region; nucleoplasm; nucleus; protein complex; secretory granule

Molecular Function: DNA binding; gamma-tubulin binding; H3 histone acetyltransferase activity; H4 histone acetyltransferase activity; identical protein binding; protease binding; protein binding; protein C-terminus binding; single-stranded DNA binding

Biological Process: brain development; cell aging; cell cycle; cell proliferation; cellular response to DNA damage stimulus; centrosome duplication; chordate embryonic development; chromosome organization and biogenesis; cytokinesis; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; DNA damage response, signal transduction resulting in induction of apoptosis; DNA recombination; DNA repair; double-strand break repair; double-strand break repair via homologous recombination; female gonad development; hemopoiesis; homologous chromosome orientation involved in meiotic metaphase I plate congression; inner cell mass cell proliferation; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; male meiosis I; mammary gland development; mitotic recombination-dependent replication fork processing; multicellular organism growth; negative regulation of mammary gland epithelial cell proliferation; nucleotide-excision repair; oocyte maturation; positive regulation of mitotic cell cycle; positive regulation of transcription, DNA-templated; regulation of cell proliferation; regulation of cytokinesis; regulation of transcription, DNA-templated; replication fork protection; response to gamma radiation; response to UV-C; response to X-ray; spermatogenesis; telomere maintenance via recombination

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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

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