Product Name
C2, Protein Lysate
Full Product Name
C2 Protein Lysate
Product Gene Name
C2 protein lysate
[Similar Products]
Product Synonym Gene Name
CO2; DKFZp779M0311[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P06681
Preparation and Storage
Add 200ul of distilled water. Final concentration is 1 mg/ml. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of C2 protein lysate vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
C2 protein lysate
Partial length C2 is expressed in E. coli.
Target Description: Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.
Product Categories/Family for C2 protein lysate
Protein;
NCBI/Uniprot data below describe general gene information for C2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000054
[Other Products]
NCBI GenBank Nucleotide #
NM_000063
[Other Products]
UniProt Primary Accession #
P06681
[Other Products]
UniProt Related Accession #
P06681[Other Products]
NCBI Official Full Name
complement C2 isoform 1 preproprotein
NCBI Official Synonym Full Names
complement C2
NCBI Official Symbol
C2??[Similar Products]
NCBI Official Synonym Symbols
CO2; ARMD14
??[Similar Products]
NCBI Protein Information
complement C2
UniProt Protein Name
Complement C2
UniProt Synonym Protein Names
C3/C5 convertase
Protein Family
Complement C2
UniProt Gene Name
C2??[Similar Products]
UniProt Entry Name
CO2_HUMAN
NCBI Summary for C2
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
UniProt Comments for C2
Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.
Research Articles on C2
1. The pooled ORs for rs551397, rs2274700, rs4151667, rs641153, rs1047286, rs9332739, and rs547154 in the heterozygote model were 0.53, 0.53 , 0.54, 0.48, 1.42, 0.50, and 0.52, respectively. We confirmed the protective role of C2/CFB/CFH polymorphisms in the development of Age-Related Macular Degeneration (AMD), and showed single nucleotide polymorphism in C3 was a high-risk factor for AMD
Precautions
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Disclaimer
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