Product Name
(Rhesus macaque) 5-hydroxytryptamine receptor 2A (HTR2A), Recombinant Protein
Popular Item
Full Product Name
Recombinant Macaca mulatta (Rhesus macaque) 5-hydroxytryptamine receptor 2A (HTR2A)
Product Gene Name
HTR2A recombinant protein
[Similar Products]
Product Synonym Gene Name
Recombinant (Rhesus macaque) 5-hydroxytryptamine receptor 2A (HTR2A); 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MDILCEENTS LSSTTNSLMQ LNEDTRLYSN DFNSGEANTS DAFNWTVESE NRTNLSCEGC LSPSCLSLLH LQEKNWSALL TAVVIILTIA GNILVIMAVS LEKKLQNATN YFLMSLAIAD MLLGFLVMPV SMLTILYGYR WPLPSKLCAV WIYLDVLFST ASIMHLCAIS LDRYVAIQNP IHHSRFNSRT KAFLKIIAVW TISVGISMPI PVFGLQDDSK VFKEGSCLLA DDNFVLIGSF VSFFIPLTIM VITYFLTIKS LQKEATLCVS DLGTRAKLAS FSFLPQSSLS SEKLFQRSIH RDPGSYTGRR TMQSISNEQK ACKVLGIVFF LFVVMWCPFF ITNIMAVICK ESCNEDVIGA LLNVFVWIGY LSSAVNPLVY TLFNKTYRSA FSRYIQCQYK ENKKPLQLIL VNTIPALAYK SSQLQMGQKK NSKQDAKTTD NDCSMVALGK QHSEDASKDN SDGVNEKVSC V
Chromosome Location
Chromosome: 17; NC_007874.1 (25653969..25714504, complement). Location: chromosome: 17
3D Structure
ModBase 3D Structure for P50128
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of HTR2A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
HTR2A recombinant protein
HTR2A
NCBI/Uniprot data below describe general gene information for HTR2A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001028138.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001032966.1
[Other Products]
UniProt Primary Accession #
P50128
[Other Products]
UniProt Related Accession #
P50128[Other Products]
Molecular Weight
52,603 Da[Similar Products]
NCBI Official Full Name
5-hydroxytryptamine receptor 2A
NCBI Official Symbol
HTR2A??[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; 5-HT2A receptor; serotonin receptor 2A
UniProt Protein Name
5-hydroxytryptamine receptor 2A
UniProt Synonym Protein Names
Serotonin receptor 2A
UniProt Gene Name
HTR2A??[Similar Products]
UniProt Synonym Gene Names
5-HT-2; 5-HT-2A??[Similar Products]
UniProt Entry Name
5HT2A_MACMU
UniProt Comments for HTR2A
Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production.
Subunit structure: Interacts with MPDZ and INADL. May interact with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2
By similarity.
Subcellular location: Cell membrane; Multi-pass membrane protein
By similarity. Note: Localizes to the postsynaptic thickening of axo-dendritic synapses
By similarity.
Domain: The PDZ domain-binding motif is involved in the interaction with INADL, CASK, APBA1, DLG1 and DLG4
By similarity.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family.
Research Articles on HTR2A
1. found enrichment of serotonin receptor 2A mRNA in primary visual cortex (V1) and clear activity-dependent modulatory effects of 5-HT2A receptor agonists on responses of V1 neurons.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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