For Research Use Only. Not for use in diagnostic procedures.

Affinity Purified - Liquid

Store at 4-8 degrees

Small volumes of anti-5HT1A R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The histochemical antibody for 5-HT1A receptor is generated in a rabbit against synthetic peptide sequence corresponding to amino acids 294-312 of the rat 5-HT1A receptor.

The antibody produces 4+ (maximum) labeling of 5-HT1A receptor at dilutions of 1/300 - 1/500 using biotin-streptavidin/HRP technique in rat cortex, arcuate and hippocampus. Optimal dilution will vary depending upon fixation, labeling technique and/or detection system; therefore, a dilution series is recommended. The antibody was characterized by immunohistochemistry and Western blot. Western blot showed a single band of approximately 45 kD. Preincubation of the antibody with an excess of the synthetic peptide blocked staining. Immunohistochemical staining of rat brain correlates well with Northern analysis, in situ hybridization and receptor autoradiography. BlastP database sequence homology searches confirmed that this sequence is unique to rat, mouse and human 5-HT1A receptors.

Antibodies; 5HT-Serotonins; 5HT (Serotonin) 1A Receptor; 5HT1A R

Immunohistochemistry (IHC), Western Blot (WB)

46,107 Da

5-hydroxytryptamine receptor 1A

5-hydroxytryptamine receptor 1A

5-hydroxytryptamine receptor 1A

ADRB2RL1; ADRBRL1; 5-HT-1A; 5-HT1A??[Similar Products]

5HT1A_HUMAN

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q11.2-q13

Cellular Component: dendrite; integral to plasma membrane; plasma membrane

Molecular Function: neurotransmitter receptor activity; protein binding; serotonin binding; serotonin receptor activity

Biological Process: behavioral fear response; G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; regulation of dopamine metabolic process; regulation of serotonin secretion; serotonin metabolic process; serotonin receptor signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway; synaptic transmission

Disease: Periodic Fever, Menstrual Cycle-dependent

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