Product Name
5-HT (Serotonin) 2C (5HT2C R), Antibody
Full Product Name
5-HT (Serotonin) 2C Receptor Antibody, Rabbit
Product Gene Name
anti-5HT2C R antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified - Liquid
Immunogen
synthetic peptide sequence corresponding to amino acids 439-460 of the rat 5-HT2C receptor.
Preparation and Storage
Store at 4-8 degrees
Other Notes
Small volumes of anti-5HT2C R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-5HT2C R antibody
The histochemical antibody for 5-HT2C receptor is generated in a rabbit against synthetic peptide sequence corresponding to amino acids 439-460 of the rat 5-HT2C receptor.
The antibody produces 4+ (maximum) labeling of 5-HT2C receptor at dilutions of 1/300 - 1/500 using biotin-streptavidin/HRP technique in rat choroid plexus and hippocampus. Optimal dilution will vary depending upon fixation, labeling technique and/or detection system; therefore, a dilution series is recommended. The antibody was characterized by immunohistochemistry and Western blot. Western blotting revealed a single band of approximately 70 kD. Preincubation of the antibody with an excess of the synthetic peptide blocked staining. Immunohistochemical staining of rat brain correlates well with Northern analysis, in situ hybridization and receptor autoradiography. BlastP database sequence homology searches confirmed that this sequence is unique to rat, mouse and human 5-HT2C receptors.
Product Categories/Family for anti-5HT2C R antibody
Antibodies; 5HT-Serotonins; 5HT (Serotonin) 2C Receptor; 5HT2C R
Applications Tested/Suitable for anti-5HT2C R antibody
Immunohistochemistry (IHC), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for 5HT2C R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001243689.1
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NCBI GenBank Nucleotide #
NM_001256760.2
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UniProt Secondary Accession #
Q5VUF8; Q9NP28; B1AMW4[Other Products]
UniProt Related Accession #
P28335[Other Products]
Molecular Weight
28,055 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2C isoform a
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 2C
NCBI Official Symbol
HTR2C??[Similar Products]
NCBI Official Synonym Symbols
HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C
??[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2C
UniProt Protein Name
5-hydroxytryptamine receptor 2C
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
UniProt Gene Name
HTR2C??[Similar Products]
UniProt Synonym Gene Names
HTR1C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-HT-1C; 5-HT1C??[Similar Products]
UniProt Entry Name
5HT2C_HUMAN
UniProt Comments for 5HT2C R
5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: dendrite; integral to plasma membrane; plasma membrane
Molecular Function: 5-HT2 receptor activity; drug binding; neurotransmitter receptor activity; serotonin binding; serotonin receptor activity
Biological Process: behavioral fear response; cellular calcium ion homeostasis; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of phosphatidylinositol biosynthetic process; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of neurological process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; serotonin receptor, phospholipase C activating pathway; synaptic transmission
Precautions
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