For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Purified by antigen-specific affinity chromatography.

Liquid

1ug/ul (lot specific)

This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Small volumes of anti-5-HT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that function as a neurotransmitter, a hormone, and a mitogen. The 5-HT receptor (5-hydroxytryptamine receptor) belongs to the G-protein coupled receptor 1 family.

Western Blot (WB), ELISA (EIA)

46,107 Da

5-hydroxytryptamine receptor 1A

5-hydroxytryptamine receptor 1A

5-hydroxytryptamine receptor 1A

ADRB2RL1; ADRBRL1; 5-HT-1A; 5-HT1A??[Similar Products]

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q12.3

Cellular Component: dendrite; integral to plasma membrane; plasma membrane

Molecular Function: neurotransmitter receptor activity; protein binding; serotonin binding; serotonin receptor activity

Biological Process: behavioral fear response; G-protein coupled receptor protein signaling pathway; positive regulation of cell proliferation; regulation of dopamine metabolic process; regulation of serotonin secretion; serotonin metabolic process; serotonin receptor signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway; synaptic transmission

Disease: Periodic Fever, Menstrual Cycle-dependent

von Nickisch-Rosenegk, E., et al, Insect Biochem. Mol. Biol. 26 (8-9), 817-827 (1996)

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