Product Name
(Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88), Recombinant Protein
Popular Item
Full Product Name
Recombinant Macaca mulatta (Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88)
Product Synonym Names
Recombinant (Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88); Myeloid differentiation primary response protein MyD88
Product Gene Name
MYD88 recombinant protein
[Similar Products]
Product Synonym Gene Name
MYD88[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MAAGGPGTEP AAPVSSTSSL PLAALNMRVR RRLSLFLNVR TQVAADWTAL AEEMDFEYLE IRQLETHADP TGRLLDAWQG RPGASVGRLL ELLTKLGRDD VLLELGPSIE EDCQKYILKQ QQEEAEKPLQ VAAVDSSVPR TAELAGITTL DDPLGHMPER FDAFICYCPS DIQFVQEMIR QLEQTNYRLK LCVSDRDVLP GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA LSLSPGAHQK RLIPIKYKAM KKEFPSILRF ITVCDYTNPC TKSWFWTRLA KALSLP
Chromosome Location
Chromosome: 2; NC_007859.1 (98418735..98421323, complement). Location: chromosome: 2
3D Structure
ModBase 3D Structure for B3Y683
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MYD88 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MYD88. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001124153.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001130681.1
[Other Products]
UniProt Primary Accession #
B3Y683
[Other Products]
UniProt Related Accession #
B3Y683[Other Products]
Molecular Weight
33,354 Da[Similar Products]
NCBI Official Full Name
myeloid differentiation primary response protein MyD88
NCBI Official Symbol
MYD88??[Similar Products]
NCBI Protein Information
myeloid differentiation primary response protein MyD88; myeloid differentiation primary response protein 88
UniProt Protein Name
Myeloid differentiation primary response protein MyD88
Protein Family
Myeloid differentiation primary response protein
UniProt Gene Name
MYD88??[Similar Products]
UniProt Entry Name
MYD88_MACMU
UniProt Comments for MYD88
Function: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes
By similarity.
Subunit structure: Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, IRAK1, IRAK2 and IRAK4 via their respective TIR domains. Interacts with IL1RL1. Interacts with IL18R1. Interacts with BMX and IRF7
By similarity. Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist
By similarity. Interacts with FLII
By similarity. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding
By similarity. Interacts with IRF1
By similarity.
Subcellular location: Cytoplasm
By similarity.
Domain: The intermediate domain (ID) is required for the phosphorylation and activation of IRAK
By similarity.
Sequence similarities: Contains 1 death domain.Contains 1 TIR domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
