Product Name
(Rhesus macaque) NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial, Recombinant Protein
Popular Item
Full Product Name
Recombinant Macaca mulatta (Rhesus macaque) NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial
Product Synonym Names
Recombinant (Rhesus macaque) NACHT, LRR and PYD domains-containing protein 3 (NLRP3), partial; NACHT, LRR and PYD domains-containing protein 3
Product Gene Name
NLRP3 recombinant protein
[Similar Products]
Product Synonym Gene Name
NLRP3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_007858.1 (209538542..209565686, complement). Location: chromosome: 1
3D Structure
ModBase 3D Structure for B0FPE9
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Macaca mulatta (Rhesus macaque)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of NLRP3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for NLRP3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001107823.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001114351.1
[Other Products]
UniProt Primary Accession #
B0FPE9
[Other Products]
UniProt Related Accession #
B0FPE9[Other Products]
Molecular Weight
118,192 Da[Similar Products]
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 3
NCBI Official Symbol
NLRP3??[Similar Products]
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 3; NLR family pyrin domain containing 3
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 3
Protein Family
NACHT, LRR and PYD domains-containing protein
UniProt Gene Name
NLRP3??[Similar Products]
UniProt Entry Name
NALP3_MACMU
UniProt Comments for NLRP3
Function: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18
By similarity.
Subunit structure: Interacts with PYCARD/ASC. Part of the NALP3 inflammasome complex which is involved in activation of caspase-1 and caspase-5, leading to processing of IL1B and IL18
By similarity.
Subcellular location: Cytoplasm
By similarity.
Tissue specificity: Highly expressed in oocyte, testis, spleen, thymus and kidney. Ref.1
Sequence similarities: Belongs to the NLRP family.Contains 1 DAPIN domain.Contains 9 LRR (leucine-rich) repeats.Contains 1 NACHT domain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
