5-hydroxytryptamine receptor 2A; 5-HT-2A; Serotonin receptor 2A; 5-HT-2; HTR2A

For Research Use Only. Not for use in diagnostic procedures.

5-HT-2A antibody detects endogenous levels of total 5-HT-2A protein.

Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Store at-20 degree C for 1 year.

Small volumes of anti-5-HT-2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells

Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

IHC: 1:50-1:100
IF: 1:100-1:500
ELISA: 1:5000

Peptide-+

Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue, using 5-HT-2A antibody. Immunofluorescence analysis of A549 cells, using 5-HT-2A antibody.

43,940 Da

5-hydroxytryptamine receptor 2A

5-hydroxytryptamine receptor 2A

5-hydroxytryptamine receptor 2A

HTR2; 5-HT-2; 5-HT-2A??[Similar Products]

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:28129538). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538). Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca2+ ions from intracellular stores (PubMed:18703043, PubMed:28129538). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction.

Saltzman A.G., Biochem. Biophys. Res. Commun. 181:1469-1478(1991). Chen K., Brain Res. Mol. Brain Res. 14:20-26(1992). Cook E.H. Jr., J. Neurochem. 63:465-469(1994).

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