Anti -Spastizin, CT (Zinc Finger FYVE Domain-containing Protein 26, FYVE Domain-containing Centrosomal Protein, FYVE-CENT, ZFYVE26, KIAA0321)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 15; NC_000015.9 (44854894..44955876, complement). Location: 15q14

Polyclonal

Rabbit

Recognizes human ZFYVE26. Species sequence homology: Mouse, rat.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-SPG11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Centrosomal Proteins

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Western Blot: 0.5-1ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

278,868 Da[Similar Products]

spastic paraplegia 11 (autosomal recessive)

spatacsin; spastic paraplegia 11 protein; colorectal carcinoma-associated protein

Spatacsin

KIAA1840??[Similar Products]

SPTCS_HUMAN

The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

SPG11: Defects in SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q14

Cellular Component: lysosomal membrane; cytoplasm; integral to membrane; nucleolus; plasma membrane; cytoplasmic vesicle; cytosol

Molecular Function: protein binding

Disease: Spastic Paraplegia 11, Autosomal Recessive

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