Full Product Name
GFAP antibody
Product Synonym Names
Polyclonal GFAP; Anti-GFAP; Glial Filament Protein; Glial marker; Glial Fibrillary Acid Protein
Product Gene Name
anti-GFAP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P03995
Species Reactivity
Chicken, Guinea Pig, Hamster, Human, Monkey, Mouse, Rat, Sheep
Form/Format
IgG Fraction supplied in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3.
Concentration
~1.0 mg/ml (lot specific)
Biological Significance
Glial Fibrillary Acidic Protein (GFAP) is specific to astrocytes (i.e., glial cells) and ependymal cells of the central nervous system. GFAP is a type III IF protein that maps, in humans, to 17q21. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell?s cytoskeleton.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
Immunogen
GFAP antibody was raised in rabbit using GFAP isolated from cow spinal cord as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-GFAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GFAP antibody
Rabbit polyclonal GFAP antibody
Product Categories/Family for anti-GFAP antibody
Neuroscience
Applications Tested/Suitable for anti-GFAP antibody
Immunohistochemistry (IHC) Formalin/Paraffin
Application Notes for anti-GFAP antibody
IHC-F: 1:100-1:200
IHC-P: 1:100-1:200
NCBI/Uniprot data below describe general gene information for GFAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_034407
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NCBI GenBank Nucleotide #
NM_010277.3
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UniProt Primary Accession #
P03995
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UniProt Secondary Accession #
Q09J71; Q3USS4; Q496R4; Q496S3; Q7TQ30; Q80VX6; Q925K2; Q925K3; A1E2H7; A2AH87; B2RTI7[Other Products]
UniProt Related Accession #
P03995[Other Products]
Molecular Weight
51-52 kDa (predicted detection band MW)
NCBI Official Full Name
glial fibrillary acidic protein isoform 2
NCBI Official Synonym Full Names
glial fibrillary acidic protein
NCBI Official Symbol
Gfap??[Similar Products]
NCBI Official Synonym Symbols
AI836096
??[Similar Products]
NCBI Protein Information
glial fibrillary acidic protein
UniProt Protein Name
Glial fibrillary acidic protein
Protein Family
Glial fibrillary acidic protein
UniProt Gene Name
Gfap??[Similar Products]
UniProt Synonym Gene Names
GFAP??[Similar Products]
UniProt Entry Name
GFAP_MOUSE
UniProt Comments for GFAP
GFAP: a class-III intermediate filament protein. A cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant isoform has been described, but its full length sequence has not been determined.
Protein type: Cytoskeletal
Cellular Component: cell projection; membrane; cytoplasm; intermediate filament; myelin sheath
Molecular Function: integrin binding; protein binding; structural constituent of cytoskeleton; structural molecule activity; kinase binding
Biological Process: extracellular matrix organization and biogenesis; Bergmann glial cell differentiation; regulation of neurotransmitter uptake; response to wounding; neurite regeneration; intermediate filament organization; intermediate filament-based process; astrocyte development
Research Articles on GFAP
1. Data suggest that prenatal alterations in expression of various fetal brain proteins (including down-regulation of Gfap) are associated with aberrant behavioral characteristics of transgenic mice that model autism-like behavior.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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