Full Product Name
Rabbit Polyclonal (IgG) to Bovine GFAP
Product Synonym Names
Anti-GFAP Antibody IHC-plus; GFAP; Bovine GFAP
Product Gene Name
anti-GFAP antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P14136
Species Reactivity
Bovine, Chicken, Guinea pig, Hamster, Human, Monkey, Mouse, Rat, Sheep
Purity/Purification
Purified
Form/Format
10mM PBS, pH 7.4, with 0.2% BSA and 0.09% Sodium Azide
Immunogen Description
GFAP isolated from cow spinal cord.
Immunogen
GFAP antibody was raised against gFAP isolated from cow spinal cord.
Preparation and Storage
Stable for 24 months when stored at 2-8 degree C.
Other Notes
Small volumes of anti-GFAP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GFAP antibody
Glial fibrillary acidic protein is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage. It is used frequently as an astrocyte marker.
Applications Tested/Suitable for anti-GFAP antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-GFAP antibody
IHC-P (1:50)
Immunohistochemistry (IHC) of anti-GFAP antibody
Anti-GFAP antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
NCBI/Uniprot data below describe general gene information for GFAP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002046.1
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NCBI GenBank Nucleotide #
NM_002055.4
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UniProt Primary Accession #
P14136
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UniProt Secondary Accession #
Q53H98; Q5D055; Q6ZQS3; Q7Z5J6; Q7Z5J7; Q96KS4; Q96P18; Q9UFD0; B2RD44; D3DX59; E9PAX3[Other Products]
UniProt Related Accession #
P14136[Other Products]
Molecular Weight
49,508 Da
NCBI Official Full Name
glial fibrillary acidic protein isoform 1
NCBI Official Synonym Full Names
glial fibrillary acidic protein
NCBI Official Symbol
GFAP??[Similar Products]
NCBI Protein Information
glial fibrillary acidic protein
UniProt Protein Name
Glial fibrillary acidic protein
Protein Family
Glial fibrillary acidic protein
UniProt Gene Name
GFAP??[Similar Products]
UniProt Synonym Gene Names
GFAP??[Similar Products]
UniProt Entry Name
GFAP_HUMAN
NCBI Summary for GFAP
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
UniProt Comments for GFAP
GFAP: a class-III intermediate filament protein. A cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant isoform has been described, but its full length sequence has not been determined.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: membrane; cytoplasm; intermediate filament; cytosol
Molecular Function: integrin binding; structural constituent of cytoskeleton; kinase binding
Biological Process: Bergmann glial cell differentiation; extracellular matrix organization and biogenesis; regulation of neurotransmitter uptake; response to wounding; neurite regeneration; intermediate filament organization; astrocyte development
Disease: Alexander Disease
Research Articles on GFAP
1. TBI patients showed an average 3.77 fold increase in anti-GFAP autoantibody levels from early (0-1 days) to late (7-10 days) times post injury.
Precautions
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Disclaimer
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