HTR2A; 5-HT2A; 5-HT-2A; 5-HT2a receptor; 5HT2A Receptor; 5-HT-2; 5-HT2A/2C; 5-HT2A/2C receptor; 5-HT2 receptor; HTR2; Serotonin 5-HT-2A receptor; Serotonin receptor 2A; Serotonin 2a receptor

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

5-HT-2A Antibody detects endogenous levels of total 5-HT-2A

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1.0mg/mL (lot specific)

Store at -20 degree C

Small volumes of anti-5-HT-2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Total protein Ab

Western Blot (WB)

Western Blot: 1:1000-3000

Western blot analysis 5-HT-2A using COLO205 whole cell lysates

43,940 Da

5-hydroxytryptamine receptor 2A

5-hydroxytryptamine receptor 2A

5-hydroxytryptamine receptor 2A

HTR2; 5-HT-2; 5-HT-2A??[Similar Products]

5HT2A_HUMAN

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: dendrite; plasma membrane

Molecular Function: drug binding; neurotransmitter receptor activity; serotonin binding; serotonin receptor activity

Biological Process: cellular calcium ion homeostasis; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); phosphoinositide 3-kinase cascade; phospholipase C activation; positive regulation of phosphatidylinositol biosynthetic process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; synaptic transmission

Disease: Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Major Depressive Disorder; Obsessive-compulsive Disorder; Schizophrenia

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