Product Name
5-HT1A (HTR1A), Polyclonal Antibody
Full Product Name
Anti-5-HT1A Antibody
Product Synonym Names
ADRB2RL1; ADRBRL1; 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; G-21; Serotonin receptor 1A
Product Gene Name
anti-HTR1A antibody
[Similar Products]
Antibody/Peptide Pairs
5-HT1A peptide (MBS823997) is used for blocking the activity of 5-HT1A antibody (MBS821420)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P08908
Species Reactivity
Human, Rat, Rabbit
Specificity
Recognizes endogenous levels of 5-HT1A protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human 5-HT1A. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-HTR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HTR1A antibody
Rabbit polyclonal antibody to 5-HT1A
Applications Tested/Suitable for anti-HTR1A antibody
Western Blot (WB)
Application Notes for anti-HTR1A antibody
WB (1/500 - 1/1000)
Western Blot (WB) of anti-HTR1A antibody
Western blot analysis of 5-HT1A expression in Saos2 (A), Jurkat (B) whole cell lysates.
Immunohistochemistry (IHC) of anti-HTR1A antibody
NCBI/Uniprot data below describe general gene information for HTR1A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000515.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000524.3
[Other Products]
UniProt Primary Accession #
P08908
[Other Products]
UniProt Secondary Accession #
Q6LAE7[Other Products]
UniProt Related Accession #
P08908[Other Products]
Molecular Weight
46,107 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 1A
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
NCBI Official Symbol
HTR1A??[Similar Products]
NCBI Official Synonym Symbols
G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1
??[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 1A; 5-HT1a receptor; guanine nucleotide-binding regulatory protein-coupled receptor
UniProt Protein Name
5-hydroxytryptamine receptor 1A
UniProt Synonym Protein Names
G-21; Serotonin receptor 1A
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
HTR1A??[Similar Products]
UniProt Synonym Gene Names
ADRB2RL1; ADRBRL1; 5-HT-1A; 5-HT1A??[Similar Products]
UniProt Entry Name
5HT1A_HUMAN
NCBI Summary for HTR1A
This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]
UniProt Comments for HTR1A
5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.
Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 5q11.2-q13
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: protein binding; serotonin receptor activity
Biological Process: cell proliferation; vasoconstriction; G-protein coupled receptor protein signaling pathway; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; regulation of serotonin secretion; regulation of dopamine metabolic process; positive regulation of cell proliferation; regulation of hormone secretion; serotonin metabolic process; serotonin receptor signaling pathway; regulation of behavior
Disease: Periodic Fever, Menstrual Cycle-dependent
Research Articles on HTR1A
1. An increase in somatodendritic but not postsynaptic 5-HT1A autoreceptor functions in medication-free depressed patients leads to increased receptor function in depressed patients, compared with a cohort of controls.
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