5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; G-21; Serotonin receptor 1A; HTR1A; ADRB2RL1; ADRBRL1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Purified Rabbit Polyclonal Antibody (Pab)

0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%

1mg/ml (lot specific)

Store at -20 degree C.Stable for 12 months from date of receipt

Small volumes of anti-HTR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5- hydroxytryptamine release and in the regulation of dopamine and 5- hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Cancer; Metabolism; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~ 1:1000

Anti-5-HT1A Antibody at 1:1000 dilution + human brain lysates

Lysates/proteins at 20 ug per lane.

Secondary
Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution

Predicted band size : 46 kDa

Blocking/Dilution buffer: 5% NFDM/TBST.

46107

5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

5-hydroxytryptamine receptor 1A

5-hydroxytryptamine receptor 1A

ADRB2RL1; ADRBRL1; 5-HT-1A; 5-HT1A??[Similar Products]

5HT1A_HUMAN

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 5q11.2-q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; serotonin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; vasoconstriction; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; regulation of serotonin secretion; regulation of dopamine metabolic process; positive regulation of cell proliferation; regulation of hormone secretion; serotonin metabolic process; serotonin receptor signaling pathway; regulation of behavior

Disease: Periodic Fever, Menstrual Cycle-dependent

Kobilka B.K.,et al.Nature 329:75-79(1987).
Saltzman A.G.,et al.Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases.
Levy F.O.,et al.Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases.
Kitano T.,et al.Mol. Biol. Evol. 21:936-944(2004).
Puhl H.L. III,et al.Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.

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