HTR2; 5-hydroxytryptamine receptor 2A; 5-HT-2; 5-HT-2A; Serotonin receptor 2A

For Research Use Only. Not for use in diagnostic procedures.

Synthetic

>85%

Lyophilized powder

Shipped at 4 degree C. Store at -20 degree C for one year.

Small volumes of HTR2A blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The peptide is used to block Anti-5-HT2A Antibody reactivity.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

43,940 Da

5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled

5-hydroxytryptamine receptor 2A; 5-HT-2A; 5-HT2 receptor; serotonin 5-HT-2A receptor

5-hydroxytryptamine receptor 2A

HTR2; 5-HT-2; 5-HT-2A??[Similar Products]

5HT2A_HUMAN

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

5-HT(2A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 13q14-q21

Cellular Component: cell soma; integral to plasma membrane; axon; cytoplasmic membrane-bound vesicle; plasma membrane; caveola; dendritic shaft; cytosol

Molecular Function: serotonin binding; serotonin receptor activity; protein complex binding; G-protein alpha-subunit binding; drug binding

Biological Process: urinary bladder smooth muscle contraction; cell death; phosphoinositide 3-kinase cascade; negative regulation of potassium ion transport; thermoregulation; regulation of dopamine secretion; positive regulation of MAP kinase activity; synaptic transmission; behavioral response to cocaine; positive regulation of cell proliferation; detection of temperature stimulus involved in sensory perception of pain; serotonin receptor signaling pathway; artery smooth muscle contraction; aging; regulation of behavior; response to drug; serotonin receptor, phospholipase C activating pathway; negative regulation of synaptic transmission, glutamatergic; regulation of hormone secretion; positive regulation of phosphatidylinositol biosynthetic process; sleep; memory; cellular calcium ion homeostasis; detection of mechanical stimulus involved in sensory perception of pain; positive regulation of peptidyl-tyrosine phosphorylation; phospholipase C activation; release of sequestered calcium ion into cytosol; positive regulation of glycolysis; positive regulation of vasoconstriction; positive regulation of fat cell differentiation

Disease: Schizophrenia; Alcohol Dependence; Anorexia Nervosa, Susceptibility To, 1; Obsessive-compulsive Disorder; Major Depressive Disorder

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