Product Name
5-HT2C (HTR2C), Polyclonal Antibody
Popular Item
Full Product Name
Anti-5-HT2C Antibody
Product Synonym Names
HTR1C; 5-hydroxytryptamine receptor 2C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
Product Gene Name
anti-HTR2C antibody
[Similar Products]
Antibody/Peptide Pairs
5-HT2C peptide (MBS8243609) is used for blocking the activity of 5-HT2C antibody (MBS8242072)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P28335
Species Reactivity
Human, Mouse, Dog
Specificity
Recognizes endogenous levels of 5-HT2C protein.
Purity/Purification
The antibody was purified by affinity chromatography.
Form/Format
Liquid in PBS, pH 7.3, 0.2% BSA, and 0.02% Sodium Azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human 5-HT2C. The exact sequence is proprietary.
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-HTR2C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HTR2C antibody
Rabbit polyclonal antibody to 5-HT2C
Applications Tested/Suitable for anti-HTR2C antibody
Western Blot (WB)
Application Notes for anti-HTR2C antibody
Western Blot: (1/500 - 1/1000)
Western Blot (WB) of anti-HTR2C antibody
Western blot analysis of 5-HT2C expression in SHSY5Y (A), NIH3T3 (B) whole cell lysates.
NCBI/Uniprot data below describe general gene information for HTR2C. It may not necessarily be applicable to this product.
NCBI Accession #
P28335.1
[Other Products]
UniProt Primary Accession #
P28335
[Other Products]
UniProt Secondary Accession #
Q5VUF8; Q9NP28; B1AMW4[Other Products]
UniProt Related Accession #
P28335[Other Products]
Molecular Weight
28,055 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 2C
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 2C
NCBI Official Symbol
HTR2C??[Similar Products]
NCBI Official Synonym Symbols
HTR1C; 5-HT1C; 5-HT2C; 5HTR2C; 5-HTR2C
??[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2C
UniProt Protein Name
5-hydroxytryptamine receptor 2C
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
HTR2C??[Similar Products]
UniProt Synonym Gene Names
HTR1C; 5-HT-2C; 5-HT2C; 5-HTR2C; 5-HT-1C; 5-HT1C??[Similar Products]
UniProt Entry Name
5HT2C_HUMAN
NCBI Summary for HTR2C
This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants. [provided by RefSeq, Jan 2015]
UniProt Comments for HTR2C
5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.
Protein type: GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR
Chromosomal Location of Human Ortholog: Xq24
Cellular Component: cytosol; integral to plasma membrane; plasma membrane
Molecular Function: 5-HT2 receptor activity; drug binding; serotonin binding; serotonin receptor activity
Biological Process: behavioral fear response; cellular calcium ion homeostasis; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); locomotory behavior; positive regulation of fat cell differentiation; positive regulation of phosphatidylinositol biosynthetic process; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of neurological process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway; serotonin receptor, phospholipase C activating pathway; synaptic transmission
Research Articles on HTR2C
1. Results of the present study do not support a major role of SNPs of HTR2C rs1414334 in the regulation of weight gain or association of serum levels in patients with schizophrenia on clozapine treatment.
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