Recombinant (Rhesus macaque) Tumor necrosis factor ligand superfamily member 6 (FASLG); Tumor necrosis factor ligand superfamily member 6; CD95 ligand; CD95-L Fas antigen ligand; Fas ligand; FasL CD_antigen= CD178 Cleaved into the following 4 chains: 1. T

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 1; NC_007858.1 (202356172..202363032). Location: chromosome: 1

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of FASLG recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This protein is the ligand for FAS. Both are transmembrane proteins. Interaction of FAS with this ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE).

31,368 Da[Similar Products]

tumor necrosis factor ligand superfamily member 6; CD95 ligand; FAS antigen CD95; fas antigen ligand

Tumor necrosis factor ligand superfamily member 6

CD95L; FASL; TNFSF6; CD95-L; Fas ligand; FasL; sFasL; APL; FasL ICD; SPA??[Similar Products]

TNFL6_MACMU

Function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. May be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. Binding to the decoy receptor TNFRSF6B/DcR3 modulates its effects

By similarity.The FasL intracellular domain (FasL ICD) cytoplasmic form induces gene transcription inhibition

By similarity.

Subunit structure: Homotrimer

Probable. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1

By similarity.

Subcellular location: Cell membrane; Single-pass type II membrane protein

By similarity. Cytoplasmic vesicle lumen

By similarity. Lysosome lumen

By similarity. Note: Colocalizes with the SPPL2A protease at the cell membrane. Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination

By similarity.Tumor necrosis factor ligand superfamily member 6, soluble form: Secreted

By similarity. Note: May be released into the extracellular fluid, probably by cleavage form the cell surface

By similarity.FasL intracellular domain: Nucleus

By similarity. Note: The FasL ICD cytoplasmic form is translocated into the nucleus

By similarity.

Post-translational modification: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells

By similarity.Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization

By similarity.N-glycosylated

By similarity.Monoubiquitinated

By similarity.

Sequence similarities: Belongs to the tumor necrosis factor family.

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