Product Name
SPG11, cDNA Clone
Full Product Name
SPG11 cDNA Clone
Product Gene Name
SPG11 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggggcggg ttctaccgat gctgttggtg ccagtccccg ccgaggcgat ggggcagctc ggctcccggg cgcagctgcg cacacagccg gaggctctgg ggagcctgac ggctgcgggc agcctccaag tgctttcttt gacgcctggc agccggggcg ggggtcgctg ctgcctggag ggccccttct ggcactttct atgggaggat tctcgtaaca gcagcacacc aactgaaaag cccaaactgc tcgctcttgg tgaaaattat gaactgctta tctatgaatt taatttgaaa gatggaagat gtgatgcaac cattttgtat agctgtagta gggaggcatt gcaaaagctc attgacgatc aagatatcag tatttcctta ttgtctttga gaatcctgtc atttcacaat aacacatcat tactgttcat caacaaatgt gtcatcctac atattatatt tcctgaaaga gatgctgcaa ttagagtact caactgtttc acacttccct tgcctgcaca ggcagtggac atgattattg acacgcagct ctgcagagga attctttttg ttttgagtag tttaggctgg atctacattt ttgatgttgt ggatggtaca tatgtagctc atgtggattt agcacttcac aaagaagaca tgtgtaatga gcagcaacag gagccagcca agatttcttc atttacttca ctgaaagttt ctcaagacct cgatgttgca gtgattgtca gctcctccaa ctccgcagtt gctcttaact taaatttgta tttcaggcaa cacccaggac acctactgtg tgaaagaata ctagaagatc ttcctattca aggacctaag ggcgtagatg aagatgatcc tgttaactct gcctacaaca tgaaactggc aaagttttcc ttccaaattg ataggtcttg gaaagcccag ctatcatcat tggatgaaac aataaagaac tccaaactgg aggtttcctg ttgtgctcca tggttccagg atattttgca tttggagtca cctgaatctg gtaaccacag tacaagtgtg cagagctggg ccttcattcc acaggacata atgcatgggc aatataatgt tctacagaaa gatcatgcca agaccagtga tccaggaaga tcatggaaaa taatgcacat cagtgaacaa gaggaaccca tagagcttaa atgtgtgtct gtgacaggat tcactgcact gtttacttgg gaagtggaaa ggatgggcta taccattacc ctctgggatt tggagaccca gggcatgcag tgtttttccc ttggcacaaa gtgtattcct gtagacagta gtggagacca gcagctgtgc tttgttttga cagagaatgg actctctctg attttgtttg gtttgactca agaagagttt ttaaacagac tcatgatcca tggaagtgcc agcactgtgg acactctttg tcatctcaat ggctggggaa ggtgctcaat tcccatacat gcactagagg ccgggataga aaatcgtcag ctggacacag taaatttctt tttgaagagc aaggaaaatc tttttaatcc atcctcaaaa tcttctgtat ctgatcagtt tgatcacttg tcatcccatt tatatttaag aaatgtggaa gagctgatac cagcattgga tttactttgc tcggcaatta gagaaagtta ttctgaaccc caaagcaaac acttttcaga acaattgctt aatcttacac tgtctttcct taacaaccaa ataaaggagc ttttcattca cactgaagaa ctagatgaac atctgcaaaa aggagtgaac attttgacta gctacattaa tgaacttcga accttcatga taaagtttcc ttggaagcta acagatgcta tagatgaata tgatgtacat gaaaatgtcc ccaaagtaaa ggagagcaat atatggaaga aactcagctt tgaggaagtt attgccagcg ccattttaaa caacaaaata ccagaggcac agactttctt caggattgat agtcattctg ctcaaaaact tgaggagctt attggcatag gcctaaattt ggtctttgac aatttaaaaa agaacaatat aaaggaagcc tctgaacttt tgaagaatat ggggtttgat gtaaaaggcc aattgctcaa gatctgcttc tatacaacta ataaaaatat acgtgacttt ttggtaggta aaggtgagac tacatag
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SPG11 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SPG11. It may not necessarily be applicable to this product.
NCBI Accession #
BC047416
[Other Products]
UniProt Secondary Accession #
Q4VC11; Q58G86; Q69YG6; Q6NW01; Q8N270; Q8TBU9; Q9H734; A8KAX9; B9EK60; F5H3N6[Other Products]
UniProt Related Accession #
Q96JI7[Other Products]
Molecular Weight
266,643 Da
NCBI Official Full Name
Homo sapiens KIAA1840, mRNA
NCBI Official Synonym Full Names
spastic paraplegia 11 (autosomal recessive)
NCBI Official Symbol
SPG11??[Similar Products]
NCBI Official Synonym Symbols
ALS5; CMT2X; KIAA1840
??[Similar Products]
NCBI Protein Information
spatacsin
UniProt Protein Name
Spatacsin
UniProt Synonym Protein Names
Colorectal carcinoma-associated protein; Spastic paraplegia 11 protein
UniProt Gene Name
SPG11??[Similar Products]
UniProt Synonym Gene Names
KIAA1840??[Similar Products]
UniProt Entry Name
SPTCS_HUMAN
NCBI Summary for SPG11
The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Comments for SPG11
SPG11: Defects in SPG11 are the cause of spastic paraplegia autosomal recessive type 11 (SPG11). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: cytoplasm; cytoplasmic vesicle; cytosol; lysosomal membrane; nucleolus; plasma membrane; synapse
Molecular Function: protein binding
Biological Process: axon cargo transport; synaptic transmission; synaptic vesicle transport
Disease: Charcot-marie-tooth Disease, Axonal, Type 2x; Spastic Paraplegia 11, Autosomal Recessive
Research Articles on SPG11
1. SPG11 is the causative gene of a wide spectrum of clinical features, including autosomal recessive axonal Charcot-Marie-Tooth disease. 1
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Disclaimer
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