Product Name
Endoplasmic reticulum aminopeptidase 1 (Erap1), Recombinant Protein
Full Product Name
Recombinant Rat Endoplasmic reticulum aminopeptidase 1 (Erap1) , partial
Product Gene Name
Erap1 recombinant protein
[Similar Products]
Product Synonym Gene Name
Erap1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
731-930,Fragment at the C-terminal.
Sequence
LCVQRAERYF REWKASNGNM SLPIDVTLAV FAVGAQNTEG WDFLYSKYQS SLSSTEKSQI EFSLCISQDP EKLQWLLDQS FKGEIIKTQE FPHILTLIGR NPVGYPLAWK FLKENWNKIV QKFELGSSSI AHMVMGTTNQ FSTRARLEEV KGFFSSLKKN GSQLRCVQQT IETIEENIRW MDKNFDKIRL WLQKERQELL
3D Structure
ModBase 3D Structure for Q9JJ22
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Erap1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Erap1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_110463.1
[Other Products]
NCBI GenBank Nucleotide #
NM_030836.1
[Other Products]
UniProt Primary Accession #
Q9JJ22
[Other Products]
UniProt Secondary Accession #
Q9JJ23[Other Products]
UniProt Related Accession #
Q9JJ22[Other Products]
Molecular Weight
100,730 Da
NCBI Official Full Name
endoplasmic reticulum aminopeptidase 1
NCBI Official Synonym Full Names
endoplasmic reticulum aminopeptidase 1
NCBI Official Symbol
Erap1??[Similar Products]
NCBI Official Synonym Symbols
Arts1; Appils
??[Similar Products]
NCBI Protein Information
endoplasmic reticulum aminopeptidase 1
UniProt Protein Name
Endoplasmic reticulum aminopeptidase 1
UniProt Synonym Protein Names
ARTS-1; Adipocyte-derived leucine aminopeptidase; A-LAP; Aminopeptidase PILS; Puromycin-insensitive leucyl-specific aminopeptidase; PILS-AP
Protein Family
Endoplasmic reticulum aminopeptidase
UniProt Gene Name
Erap1??[Similar Products]
UniProt Synonym Gene Names
Appils; Arts1; A-LAP; PILS-AP??[Similar Products]
NCBI Summary for Erap1
aminopeptidase enzyme; catalyzes the puromycin-insensitive Zn-dependent hydrolysis of N-terminal Leu; plays a role in processing antigenic precursors for MHC class I presentation [RGD, Feb 2006]
UniProt Comments for Erap1
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney ().
Research Articles on Erap1
1. stimulates the processing and presentation of an antigenic precursor in the endoplasmic reticulum
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
