Product Name
SPG11, Polyclonal Antibody
Popular Item
Full Product Name
SPG11 Antibody
Product Synonym Names
Colorectal carcinoma associated protein; Colorectal carcinoma-associated protein; DKFZp762B1512; FLJ21439; KIAA1840; Spastic paraplegia 11 (autosomal recessive); Spastic paraplegia 11; Spastic paraplegia 11 protein; Spatacsin; SPG 11; Spg11; SPTCS_HUMAN
Product Gene Name
anti-SPG11 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q96JI7
Species Reactivity
Human, Mouse, Rat
Specificity
SPG11 antibody detects endogenous levels of SPG11.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Form/Format
Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (lot specific)
Immunogen
A synthesized peptide derived from human SPG11.
Subcellular Location
Cytosol; Nucleus
Tissue Specificity
Expressed in all structures of brain, with a high expression in cerebellum. Expressed in cortical projection neurons.
Predicted Cross Reactivity
Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
Similarity
Pig (100%), Bovine (100%), Horse (100%), Sheep (100%), Rabbit (100%), Dog (100%), Chicken (82%)
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Other Notes
Small volumes of anti-SPG11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SPG11 antibody
Function: May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.
Subunit Structure: Interacts with AP5Z1, AP5B1, AP5S1 and ZFYVE26.
Applications Tested/Suitable for anti-SPG11 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SPG11 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
Western Blot (WB) of anti-SPG11 antibody
Western blot analysis of extracts from Hnuman liver, using SPG11 antibody.
Immunohistochemistry (IHC) of anti-SPG11 antibody
MBS9603550 at 1/100 staining Mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
NCBI/Uniprot data below describe general gene information for SPG11. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001153699.1
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NCBI GenBank Nucleotide #
NM_001160227.1
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UniProt Primary Accession #
Q96JI7
[Other Products]
UniProt Secondary Accession #
Q4VC11; Q58G86; Q69YG6; Q6NW01; Q8N270; Q8TBU9; Q9H734; A8KAX9; B9EK60; F5H3N6[Other Products]
UniProt Related Accession #
Q96JI7[Other Products]
Molecular Weight
Observed: 279 kDa
Predicted: 279 kDa
NCBI Official Full Name
spatacsin isoform 2
NCBI Official Synonym Full Names
SPG11, spatacsin vesicle trafficking associated
NCBI Official Symbol
SPG11??[Similar Products]
NCBI Official Synonym Symbols
ALS5; CMT2X; KIAA1840
??[Similar Products]
NCBI Protein Information
spatacsin
UniProt Protein Name
Spatacsin
UniProt Synonym Protein Names
Colorectal carcinoma-associated protein; Spastic paraplegia 11 protein
UniProt Gene Name
SPG11??[Similar Products]
UniProt Synonym Gene Names
KIAA1840??[Similar Products]
NCBI Summary for SPG11
The protein encoded by this gene is a potential transmembrane protein that is phosphorylated upon DNA damage. Defects in this gene are a cause of spastic paraplegia type 11 (SPG11). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Comments for SPG11
May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport.
Research Articles on SPG11
1. SPG11 was suspected to be the most common subtype of autosomal recessive hereditary spastic paraplegia in China, whereas SPG15, SPG5 or SPG7 are rare. The core symptoms of Chinese SPG11 patients showed no difference when compared to SPG11 in western countries, and clinical heterogeneity also existed in our SPG11 patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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