Human 5-hydroxytryptamine receptor 1B (HTR1B) ELISA kit; 5-HT1B; 5-HT1DB; HTR1D2; HTR1DB; S12; ; 5-hydroxytryptamine (serotonin) receptor 1B

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of HTR1B elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9325913 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HTR1B. The ELISA analytical biochemical technique of the MBS9325913 kit is based on HTR1B antibody-HTR1B antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HTR1B antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HTR1B. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

43,568 Da

5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

5-hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT-1D-beta; serotonin receptor 1B; serotonin 1D beta receptor

5-hydroxytryptamine receptor 1B

HTR1DB; 5-HT-1B; 5-HT1B; 5-HT-1D-beta??[Similar Products]

5HT1B_HUMAN

The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]

5-HT(1B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 6q13

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: serotonin binding; serotonin receptor activity; drug binding

Biological Process: vasoconstriction; drinking behavior; negative regulation of synaptic transmission, glutamatergic; response to mineralocorticoid stimulus; bone remodeling; response to cocaine; regulation of dopamine secretion; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of serotonin secretion; negative regulation of cAMP biosynthetic process; response to ethanol; serotonin receptor, adenylate cyclase inhibiting pathway; G-protein coupled receptor internalization; protein kinase C activation; negative regulation of synaptic transmission, GABAergic; regulation of behavior

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