5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; Serotonin receptor 1A; Htr1a; 5ht1a

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purified

Colorless liquid
100 ug (0.5 mg/ml) of antibody in PBS; pH 7.4; 1% BSA; 0.05% NaN3.

1 mg/ml (lot specific)

Store at -20 degree C for 12 months.
The antibody solution should be gently mixed before use.

Small volumes of anti-Htr1a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Polyclonal antibody against EDG7.
Serotonin [5-hydroxytryptamine (5-HT1) ] is an important neurotransmitter in the CNS that exerts its neuronal activity via 5-HT receptors. 5-HT receptors are subdivided into seven families termed 5-HT1 through 5-HT7.1 The 5-HT receptor families belong to the G-Protein Coupled receptor superfamily with the exception of 5-HT3 receptor class which belongs to the ligand-gated ion channels. The 5-HT1 receptor class comprises of five different receptors (5-HT1A; 5-HT1B; 5-HT1D; 5-HT1e AND 5-HT1F) which share 41-63% overall sequence identity and couple preferentially to Gi/Go to inhibit cAMP formation. The 5-HT1A receptor is the most widespread of all the 5-HT receptors. In the central nervous system; 5-HT1A receptors exist in the cerebral cortex; hippocampus; septum; amygdala and raphe nucelus in high densities; and was also demonstrated in a variety of tissues from various species. Activation of 5-HT1A receptor decreases blood pressure and heart rate; involved in learning; memory; relieving anxiety and depression. 5-Hydroxytryptamine Receptor.

GPCR

Western Blot (WB); Immunohistochemistry (IHC)

WB: 1:200-1:2000
IHC: 1:100

46,429 Da[Similar Products]

5-hydroxytryptamine receptor 1A

5-hydroxytryptamine receptor 1A

5-hydroxytryptamine receptor 1A

5ht1a; 5-HT-1A; 5-HT1A??[Similar Products]

regulates AMPA receptor channels in the prefrontal cortex; regulation is mediated via inhibition of Ca2+/calmodulin-dependent kinase II [RGD, Feb 2006]

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q13

Cellular Component: axon hillock; cell soma; integral to plasma membrane; membrane

Molecular Function: drug binding; G-protein alpha-subunit binding; neurotransmitter receptor activity; protein binding; receptor binding; serotonin binding; serotonin receptor activity

Biological Process: behavioral fear response; G-protein coupled receptor protein signaling pathway; positive regulation of microtubule depolymerization; regulation of dopamine metabolic process; regulation of serotonin secretion; serotonin metabolic process; serotonin receptor signaling pathway; serotonin receptor, adenylate cyclase inhibiting pathway

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