Product Name
C5AR1/CD88/C5a Receptor, Polyclonal Antibody
Full Product Name
Anti-C5AR1/CD88/C5a Receptor Antibody
Product Synonym Names
Rabbit Polyclonal to Human C5AR1/CD88/C5a Receptor; C5AR1; C5A; C5a-R; C5a ligand; C5a receptor; CD88; C5a anaphylatoxin receptor; C5AR; C5R1; CD88 antigen
Product Gene Name
anti-C5AR1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21730
Specificity
The antibody recognizes human complement C5a and its dimer form. Reactivity to other species has not been tested
Purity/Purification
Affinity Purified
Form/Format
PBS, 30% glycerol, 0.5% BSA, 0.01% Thimerosal.
Immunogen
Recombinant human Complement C5a.
Preparation and Storage
Short term: -20 degree C
Long term: -70 degree C.
Other Notes
Small volumes of anti-C5AR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-C5AR1 antibody
for the chemotactic and inflammatory peptide anaphylatoxin C5a. Thisreceptor stimulates chemotaxis, granule enzyme release and superoxideanion production.
Product Categories/Family for anti-C5AR1 antibody
GPCR; Anaphylatoxin
Applications Tested/Suitable for anti-C5AR1 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
Application Notes for anti-C5AR1 antibody
IHC-P: 5 ug/ml
Immunohistochemistry (IHC) of anti-C5AR1 antibody
Anti-C5AR1/CD88/C5a Receptor antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western Blot (WB) of anti-C5AR1 antibody
Western blot of CD88/C5A Receptor antibody.
NCBI/Uniprot data below describe general gene information for C5AR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001727.1
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NCBI GenBank Nucleotide #
NM_001736.3
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UniProt Primary Accession #
P21730
[Other Products]
UniProt Related Accession #
P21730[Other Products]
Molecular Weight
39,336 Da
NCBI Official Full Name
C5a anaphylatoxin chemotactic receptor 1
NCBI Official Synonym Full Names
complement C5a receptor 1
NCBI Official Symbol
C5AR1??[Similar Products]
NCBI Official Synonym Symbols
C5A; C5AR; C5R1; CD88
??[Similar Products]
NCBI Protein Information
C5a anaphylatoxin chemotactic receptor 1
UniProt Protein Name
C5a anaphylatoxin chemotactic receptor 1
UniProt Synonym Protein Names
C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88
Protein Family
C5a anaphylatoxin chemotactic receptor
UniProt Gene Name
C5AR1??[Similar Products]
UniProt Synonym Gene Names
C5AR; C5R1; C5a-R; C5aR??[Similar Products]
UniProt Comments for C5AR1
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Research Articles on C5AR1
1. the role of the active fragment complement C5a receptor (C5aR) in dental nerve regeneration in regards to local secretion of nerve growth factor (NGF) upon carious injury.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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