C5AR1; C5AR; C5R1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD88

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purification

1mg/mL (lot specific)

Store at -20 degree C. Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-CD88 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Western Blot (WB), ELISA (EIA)

WB: 1:500-1:2000
ELISA: 1:10000

Western Blot analysis of Mouse brain, Rat spleen using CD88 Polyclonal Antibody at dilution of 1:1000.

Western Blot analysis of various cells using CD88 Polyclonal Antibody at dilution of 1:1000.

Calculated Molecular Weight: 39kDa
Observed Molecular Weight: 39kDa

complement C5a receptor 1

C5a anaphylatoxin chemotactic receptor 1

C5a anaphylatoxin chemotactic receptor 1

C5AR; C5R1; C5a-R; C5aR??[Similar Products]

C5aR: a family 1 G-protein coupled receptor that stimulates the GTPase activity of Gi2. Receptor for the chemotactic and inflammatory complement factor C5a. Stimulates chemotaxis, granule enzyme release and superoxide anion production. Phosphorylated in response to C5a or after stimulation of cells with phorbol esters. Expressed on monocytes, granulocytes, dendritic cells, astrocytes and microglia.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: apical part of cell; basolateral plasma membrane; cell surface; integral component of plasma membrane; plasma membrane; secretory granule membrane

Molecular Function: complement component C5a binding; complement component C5a receptor activity; G-protein coupled receptor activity

Biological Process: activation of MAPK activity; activation of phospholipase C activity; apoptosis; cell proliferation in hindbrain; cellular defense response; chemotaxis; complement component C5a signaling pathway; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; G-protein coupled receptor signaling pathway; immune response; inflammatory response; leukocyte migration; mRNA transcription from RNA polymerase II promoter; negative regulation of neuron apoptosis; neutrophil chemotaxis; neutrophil degranulation; organ regeneration; phospholipase C-activating G-protein coupled receptor signaling pathway; positive regulation of angiogenesis; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of macrophage chemotaxis; positive regulation of neutrophil chemotaxis; positive regulation of vascular endothelial growth factor production; regulation of complement activation; response to lipopolysaccharide; response to peptidoglycan; sensory perception of chemical stimulus; signal transduction

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