Full Product Name
CD88/C5aR (Phospho-Ser338) Antibody
Product Synonym Names
C5AR; C5AR1; C5R1; C5a anaphylatoxin chemotactic receptor; C5a-R; CD88 antigen
Product Gene Name
anti-CD88/C5aR antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21730
Species Reactivity
Human, Mouse
Specificity
CD88/C5aR (Phospho-Ser338) antibody detects endogenous levels of CD88/C5aR only when phosphorylated at serine 338.
Purity/Purification
Affinity-purified fromrabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human CD88/C5aR around the phosphorylation site of serine 338 (T-R-SP-T-V).
All Sites
Human: Ser338
Mouse: Ser335
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CD88/C5aR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CD88/C5aR antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-CD88/C5aR antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-CD88/C5aR antibody
IHC: 1:50-1:100
ELISA: 1:40000
Immunohistochemistry (IHC) of anti-CD88/C5aR antibody
P-peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using CD88/C5aR (Phospho-Ser338) antibody.
NCBI/Uniprot data below describe general gene information for CD88/C5aR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001727.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001736.3
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UniProt Primary Accession #
P21730
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UniProt Related Accession #
P21730[Other Products]
Molecular Weight
39,336 Da
NCBI Official Full Name
C5a anaphylatoxin chemotactic receptor 1
NCBI Official Synonym Full Names
complement C5a receptor 1
NCBI Official Symbol
C5AR1??[Similar Products]
NCBI Official Synonym Symbols
C5A; C5AR; C5R1; CD88
??[Similar Products]
NCBI Protein Information
C5a anaphylatoxin chemotactic receptor 1
UniProt Protein Name
C5a anaphylatoxin chemotactic receptor 1
UniProt Synonym Protein Names
C5a anaphylatoxin chemotactic receptor; C5a-R; C5aR; CD_antigen: CD88
UniProt Gene Name
C5AR1??[Similar Products]
UniProt Synonym Gene Names
C5AR; C5R1; C5a-R; C5aR??[Similar Products]
UniProt Comments for CD88/C5aR
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Product References and Citations for anti-CD88/C5aR antibody
Gerard N.P., Nature 349:614-617(1991). Boulay F., Biochemistry 30:2993-2999(1991). Gerard N.P., Biochemistry 32:1243-1250(1993). Farzan M., J. Exp. Med. 193:1059-1066(2001).
Research Articles on CD88/C5aR
1. the role of the active fragment complement C5a receptor (C5aR) in dental nerve regeneration in regards to local secretion of nerve growth factor (NGF) upon carious injury.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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