Full Product Name
FCRL3 Antibody - middle region
Product Gene Name
anti-FCRL3 antibody
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Antibody/Peptide Pairs
FCRL3 peptide (MBS3234803) is used for blocking the activity of FCRL3 antibody (MBS3209848)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: RGSSLSDAVH VEFSPDWLIL QALHPVFEGD NVILRCQGKD NKNTHQKVYY
3D Structure
ModBase 3D Structure for Q96P31
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human FCRL3
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-FCRL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FCRL3 antibody
This is a rabbit polyclonal antibody against FCRL3. It was validated on Western Blot
Target Description: This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus.
Product Categories/Family for anti-FCRL3 antibody
Polyclonal; Signaling Intermediate; Immunology; Disease Related;
Applications Tested/Suitable for anti-FCRL3 antibody
Western Blot (WB)
Western Blot (WB) of anti-FCRL3 antibody
Host: Rabbit
Target Name: FCRL3
Sample Type: OVCAR-3 Whole cell lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for FCRL3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_443171.2
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NCBI GenBank Nucleotide #
NM_052939.4
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UniProt Primary Accession #
Q96P31
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UniProt Related Accession #
Q96P31[Other Products]
NCBI Official Full Name
Fc receptor-like protein 3 isoform 1
NCBI Official Synonym Full Names
Fc receptor like 3
NCBI Official Symbol
FCRL3??[Similar Products]
NCBI Official Synonym Symbols
FCRH3; IFGP3; IRTA3; SPAP2; CD307c
??[Similar Products]
NCBI Protein Information
Fc receptor-like protein 3
UniProt Protein Name
Fc receptor-like protein 3
UniProt Synonym Protein Names
Fc receptor homolog 3; FcRH3; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD_antigen: CD307c
Protein Family
Fc receptor-like protein
UniProt Gene Name
FCRL3??[Similar Products]
UniProt Synonym Gene Names
FCRH3; IFGP3; IRTA3; SPAP2; FcR-like protein 3; FcRL3; FcRH3; hIFGP3??[Similar Products]
UniProt Entry Name
FCRL3_HUMAN
NCBI Summary for FCRL3
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Comments for FCRL3
FCRL3: Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: integral to membrane; plasma membrane
Research Articles on FCRL3
1. no association between the FCRL-3 rs7528684 SNP with susceptibility to allergic asthma in Iranian North-Western Azeri population.
Precautions
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Disclaimer
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