Fc receptor-like protein 3; FcR-like protein 3; FcRL3; Fc receptor homolog 3; FcRH3; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD307c; FCRL3; FCRH3; IFGP3; IRTA3; SPAP2

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This FCRL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 694-720 amino acids from the C-terminal region of human FCRL3.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-FCRL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the immunoglobulin receptor
superfamily and is one of several Fc receptor-like glycoproteins
clustered on the long arm of chromosome 1. The encoded protein
contains immunoreceptor-tyrosine activation motifs and
immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain
and may play a role in regulation of the immune system. Mutations
in this gene have been associated with rheumatoid arthritis,
autoimmune thyroid disease, and systemic lupus erythematosus.

Immunology

Western Blot (WB), ELISA (EIA)

WB~~1:1000

FCRL3 Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the FCRL3 antibody detected the FCRL3 protein (arrow).

80856

Fc receptor-like 3

Fc receptor-like protein 3

Fc receptor-like protein 3

FCRH3; IFGP3; IRTA3; SPAP2; FcR-like protein 3; FcRL3; FcRH3; hIFGP3??[Similar Products]

FCRL3_HUMAN

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. [provided by RefSeq, Jul 2008]

FCRL3: Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: integral to membrane; plasma membrane

Wu, H., et al. Hum. Immunol. (2010) In press :
Swainson, L.A., et al. J. Immunol. 184(7):3639-3647(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Zheng, R., et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 26(6):681-685(2009)
Gibson, A.W., et al. Arthritis Rheum. 60(11):3510-3512(2009)

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