Full Product Name
FCRL3 Antibody
Product Synonym Names
FCRH3; IFGP3; IRTA3; SPAP2
Product Gene Name
anti-FCRL3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of FCRL3
Calculated Molecular Weight: 742aa; 82kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-FCRL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-FCRL3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for FCRL3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_443171.2
[Other Products]
NCBI GenBank Nucleotide #
NM_052939.3
[Other Products]
UniProt Secondary Accession #
Q5VXZ8; Q8N6S2; Q96LA4; Q96P27; Q96P28; Q96P29; Q96P30; A0N0M4; A8MTH7; D3DVD2[Other Products]
UniProt Related Accession #
Q96P31[Other Products]
Molecular Weight
77,921 Da
NCBI Official Full Name
Fc receptor-like protein 3
NCBI Official Synonym Full Names
Fc receptor-like 3
NCBI Official Symbol
FCRL3??[Similar Products]
NCBI Official Synonym Symbols
FCRH3; IFGP3; IRTA3; SPAP2; CD307c
??[Similar Products]
NCBI Protein Information
Fc receptor-like protein 3; Fc receptor homolog 3; IFGP family protein 3; SH2 domain-containing phosphatase anchor protein 2; fcR-like protein 3; hIFGP3; immune receptor translocation-associated protein 3; immunoglobulin superfamily receptor translocation associated protein 3
UniProt Protein Name
Fc receptor-like protein 3
UniProt Synonym Protein Names
Fc receptor homolog 3; FcRH3; IFGP family protein 3; hIFGP3; Immune receptor translocation-associated protein 3; SH2 domain-containing phosphatase anchor protein 2; CD_antigen: CD307c
Protein Family
Fc receptor-like protein
UniProt Gene Name
FCRL3??[Similar Products]
UniProt Synonym Gene Names
FCRH3; IFGP3; IRTA3; SPAP2; FcR-like protein 3; FcRL3; FcRH3; hIFGP3??[Similar Products]
UniProt Entry Name
FCRL3_HUMAN
NCBI Summary for FCRL3
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. [provided by RefSeq, Jul 2008]
UniProt Comments for FCRL3
FCRL3: Genetic variation in FCRL3 may be a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q21-q22
Cellular Component: integral to membrane; plasma membrane
Research Articles on FCRL3
1. C polymorphism is not a risk factor of systemic lupus erythematosus in the Polish population, but this polymorphism may contribute to autoantibody production in this disease.">CONCLUSIONS: Our study demonstrated that the FCRL3 -169T>C polymorphism is not a risk factor of systemic lupus erythematosus in the Polish population, but this polymorphism may contribute to autoantibody production in this disease.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
