Full Product Name
Rabbit Polyclonal (IgG) to Human ABCB5
Product Synonym Names
Anti-ABCB5 Antibody IHC-plus; ABCB5; ABCB5alpha; ABCB5 P-gp; ABCB5beta; ATP-binding cassette protein; EST422562; P-glycoprotein ABCB5; Human ABCB5
Product Gene Name
anti-ABCB5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q2M3G0
Specificity
This Polyclonal antibody is directed against human ABCB5 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human ABCB5. Cross-reactivity with ABCB5 from other sources has not been determined.
Purity/Purification
Affinity Purified
Form/Format
PBS, pH 7.4, 0.02% sodium azide
Concentration
1 mg/ml (lot specific)
Immunogen Description
Synthetic peptide
Immunogen Type
Synthetic peptide
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Other Notes
Small volumes of anti-ABCB5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ABCB5 antibody
Subfamily:-ATP-binding-cassette---ABCB/MDR">Family: Transporter
Subfamily: ATP-binding cassette - ABCB/MDR
Applications Tested/Suitable for anti-ABCB5 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-ABCB5 antibody
IHC-P (2.5 ug/ml), WB (1:1000 - 1:4000)
Immunohistochemistry (IHC) of anti-ABCB5 antibody
Anti-ABCB5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
NCBI/Uniprot data below describe general gene information for ABCB5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_848654.3
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NCBI GenBank Nucleotide #
NM_178559.5
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UniProt Primary Accession #
Q2M3G0
[Other Products]
UniProt Secondary Accession #
Q2M3I5; Q5I5Q7; Q5I5Q8; Q6KG50; A4D131; A7BKA4; B5MD19; B7WPL1; F8QQP8; F8QQP9; J3KQ04[Other Products]
UniProt Related Accession #
Q2M3G0[Other Products]
Molecular Weight
89,832 Da
NCBI Official Full Name
ATP-binding cassette sub-family B member 5 isoform 2
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family B (MDR/TAP), member 5
NCBI Official Symbol
ABCB5??[Similar Products]
NCBI Official Synonym Symbols
ABCB5beta; EST422562; ABCB5alpha
??[Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family B member 5; ABCB5 P-gp; P-glycoprotein ABCB5; ATP-binding cassette protein
UniProt Protein Name
ATP-binding cassette sub-family B member 5
UniProt Synonym Protein Names
ABCB5 P-gp; P-glycoprotein ABCB5
Protein Family
ABC transporter B family
UniProt Gene Name
ABCB5??[Similar Products]
UniProt Entry Name
ABCB5_HUMAN
NCBI Summary for ABCB5
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]
UniProt Comments for ABCB5
ABCB5: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, ABC family
Chromosomal Location of Human Ortholog: 7p21.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: efflux transmembrane transporter activity; ATPase activity, coupled to transmembrane movement of substances; ATP binding
Biological Process: regulation of membrane potential; metabolic process; compound eye corneal lens development; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; cell differentiation; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; transmembrane transport; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
Research Articles on ABCB5
1. Suggest that the helicase HAGE has a key role in the resistance of ABCB5+ malignant melanoma stem cells to IFNalpha treatment by promoting SOCS1 expression.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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