For Research Use Only. Not for use in diagnostic procedures.

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Small volumes of Aicda elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2888216 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Activation-induced cytidine deaminase (Aicda) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Aicda. The ELISA analytical biochemical technique of the MBS2888216 kit is based on Aicda antibody-Aicda antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Aicda antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Aicda. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

22,614 Da

activation induced cytidine deaminase

single-stranded DNA cytosine deaminase

Single-stranded DNA cytosine deaminase

AID; AID??[Similar Products]

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]

AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family.

Protein type: EC 3.5.4.38; Hydrolase

Chromosomal Location of Human Ortholog: 12p13.31

Cellular Component: cytoplasm; exosome (RNase complex); nucleus

Molecular Function: cytidine deaminase activity; identical protein binding; protein binding; ubiquitin protein ligase binding; zinc ion binding

Biological Process: B cell differentiation; cytidine deamination; defense response to bacterium; isotype switching; mRNA processing; negative regulation of methylation-dependent chromatin silencing; regulation of DNA stability; somatic diversification of immunoglobulins; somatic hypermutation of immunoglobulin genes

Disease: Immunodeficiency With Hyper-igm, Type 2

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