Product Name
Acyl-CoA synthetase family member 3, mitochondrial (ACSF3), Recombinant Protein
Full Product Name
Recombinant Human Acyl-CoA synthetase family member 3, mitochondrial (ACSF3)
Product Gene Name
ACSF3 recombinant protein
[Similar Products]
Product Synonym Gene Name
ACSF3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
84-576aa, Full Length of Mature Protein
Sequence
RLCGCVGGDL REERVSFLCA NDASYVVAQW ASWMSGGVAV PLYRKHPAAQ LEYVICDSQS SVVLASQEYL ELLSPVVRKL GVPLLPLTPA IYTGAVEEPA EVPVPEQGWR NKGAMIIYTS GTTGRPKGVL STHQNIRAVV TGLVHKWAWT KDDVILHVLP LHHVHGVVNA LLCPLWVGAT CVMMPEFSPQ QVWEKFLSSE TPRINVFMAV PTIYTKLMEY YDRHFTQPHA QDFLRAVCEE KIRLMVSGSA ALPLPVLEKW KNITGHTLLE RYGMTEIGMA LSGPLTTAVR LPGSVGTPLP GVQVRIVSEN PQREACSYTI HAEGDERGTK VTPGFEEKEG ELLVRGPSVF REYWNKPEET KSAFTLDGWF KTGDTVVFKD GQYWIRGRTS VDIIKTGGYK VSALEVEWHL LAHPSITDVA VIGVPDMTWG QRVTAVVTLR EGHSLSHREL KEWARNVLAP YAVPSELVLV EEIPRNQMGK IDKKALIRHF HPS
3D Structure
ModBase 3D Structure for Q4G176
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of ACSF3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for ACSF3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001120686.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001127214.3
[Other Products]
UniProt Primary Accession #
Q4G176
[Other Products]
UniProt Secondary Accession #
Q6INA0; Q8N2F7; A8K4J8; C9JQL6[Other Products]
UniProt Related Accession #
Q4G176[Other Products]
Molecular Weight
64,130 Da
NCBI Official Full Name
acyl-CoA synthetase family member 3, mitochondrial isoform 1
NCBI Official Synonym Full Names
acyl-CoA synthetase family member 3
NCBI Official Symbol
ACSF3??[Similar Products]
NCBI Protein Information
acyl-CoA synthetase family member 3, mitochondrial
UniProt Protein Name
Acyl-CoA synthetase family member 3, mitochondrial
Protein Family
Acyl-CoA synthetase family
UniProt Gene Name
ACSF3??[Similar Products]
NCBI Summary for ACSF3
This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Sep 2013]
UniProt Comments for ACSF3
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
Research Articles on ACSF3
1. an essential role for ACSF3 in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
