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Thyroglobulin, Native Protein

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產(chǎn)品名稱: Thyroglobulin, Native Protein
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Thyroglobulin, Native Protein


Thyroglobulin, Native Protein  的詳細(xì)介紹
Product Name

Thyroglobulin (TG), Native Protein

Popular Item
Full Product Name

Human Thyroglobulin

Product Synonym Names
Thyroglobulin Human; Thyroglobulin Human; Thyroglobulin; TGN; AITD3; TG; Thyroglobulin
Product Gene Name

TG native protein

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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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OMIM
188450
3D Structure
ModBase 3D Structure for P01266
Host
Native, Isolated from human thyroid glands
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Form/Format
Human Thyroglobulin is supplied in 16mM HEPES buffer pH-7.6, 240mM sodium chloride, and 20% glycerol.
Sterile Filtered solution.
Concentration
Coating Concentration: 0.7-1 ug/ml (depending on the type of ELISA plate and coating buffer).Suitable for biotinylation and iodination. (lot specific)
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.
Other Notes
Small volumes of TG native protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for
TG native protein
Description: Human Thyroglobulin is a glycosylated, polypeptide chain having a total molecular mass of 662 kDa (331 kDa per subunit).

Introduction: Thyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen.Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease.
Product Categories/Family for TG native protein
RECOMBINANT & NATURAL PROTEINS; Natural Proteins
NCBI/Uniprot data below describe general gene information for TG. It may not necessarily be applicable to this product.
NCBI GI #
55770862
NCBI GeneID
7038
NCBI Accession #
NP_003226.4 [Other Products]
NCBI GenBank Nucleotide #
NM_003235.4 [Other Products]
UniProt Primary Accession #
P01266 [Other Products]
UniProt Secondary Accession #
O15274; O43899; Q15593; Q15948; Q9NYR1; Q9NYR2; Q9UMZ0; Q9UNY3[Other Products]
UniProt Related Accession #
P01266[Other Products]
Molecular Weight
298,383 Da[Similar Products]
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NCBI Official Full Name
thyroglobulin
NCBI Official Synonym Full Names
thyroglobulin
NCBI Official Symbol
TG??[Similar Products]
NCBI Official Synonym Symbols
TGN; AITD3
??[Similar Products]
NCBI Protein Information
thyroglobulin
UniProt Protein Name
Thyroglobulin
Protein Family
Thyroglobulin
UniProt Gene Name
TG??[Similar Products]
UniProt Synonym Gene Names
Tg??[Similar Products]
UniProt Entry Name
THYG_HUMAN
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NCBI Summary for TG
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
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UniProt Comments for TG
TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity

Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process

Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3
Research Articles on TG
1. Data suggest that serum thyroglobulin levels are up-regulated in patients with well-differentiated thyroid cancers as compared to patients with benign thyroid nodules.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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