Product Name
Thyroglobulin (TG), Protein
Full Product Name
Human thyroglobulin
Product Gene Name
TG protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P01266
Form/Format
Lyophilized from 25 mM Tris-HCl, pH8.
It is recommended to reconstitute the product in distilled water.
Source Note
Human thyroid gland.
Blood sample from the tissue donor was tested and found negative for HBsAg, HIV-1 and HIV-2 antibodies, and HCV.
Analysis
Purity > 90 % (SDS-PAGE).
Immunological identity confirmed by reaction with monoclonal antibody that is specific for the human thyroglobulin.
Preparation and Storage
At -20 degree C
Other Notes
Small volumes of TG protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Application Notes for TG protein
Human thyroglobulin is suitable for use as a standard in immunoassay for determination of serum thyroglobulin levels, immunogen for antisera production, and tracer for iodination.
NCBI/Uniprot data below describe general gene information for TG. It may not necessarily be applicable to this product.
NCBI Accession #
CAA29104.1
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UniProt Primary Accession #
P01266
[Other Products]
UniProt Secondary Accession #
O15274; O43899; Q15593; Q15948; Q9NYR1; Q9NYR2; Q9UMZ0; Q9UNY3[Other Products]
UniProt Related Accession #
P01266[Other Products]
Molecular Weight
298,383 Da[Similar Products]
NCBI Official Full Name
thyroglobulin
NCBI Official Synonym Full Names
thyroglobulin
NCBI Official Symbol
TG??[Similar Products]
NCBI Official Synonym Symbols
TGN; AITD3
??[Similar Products]
NCBI Protein Information
thyroglobulin
UniProt Protein Name
Thyroglobulin
Protein Family
Thyroglobulin
UniProt Gene Name
TG??[Similar Products]
UniProt Synonym Gene Names
Tg??[Similar Products]
UniProt Entry Name
THYG_HUMAN
NCBI Summary for TG
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
UniProt Comments for TG
TG: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3). A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3). AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Belongs to the type-B carboxylesterase/lipase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 8q24
Cellular Component: extracellular space; extracellular region
Molecular Function: hormone activity
Biological Process: regulation of myelination; iodide transport; thyroid gland development; hormone biosynthetic process; signal transduction; thyroid hormone metabolic process
Disease: Thyroid Dyshormonogenesis 3; Autoimmune Thyroid Disease, Susceptibility To, 3
Research Articles on TG
1. Data suggest that serum thyroglobulin levels are up-regulated in patients with well-differentiated thyroid cancers as compared to patients with benign thyroid nodules.
Precautions
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