Anti -5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase/IMP Cyclohydrolase (ATIC, AICAR, AICAR Transformylase, AICARFT, AICARFT/IMPCHASE, IMP Cyclohydrolase, IMPCHASE, IMP Synthetase, Inosinicase, Phosphoribosylaminoimidazolecarboxamide Formyltran

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (216176679..216214496). Location: 2q35

Monoclonal

IgG1

10B231

Mouse

Recognizes ATIC. Species Crossreactivity: Mouse, rat, human, xenopus, and drosophila

Affinity Purified
Purified by Protein G affinity chromatography.

Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Small volumes of anti-ATIC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Carbohydrates, Glycoproteins

Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in Immunohistochemistry (paraffin) and Western Blot.
Dilution: Immunohistochemistry (paraffin): 1:50-1:500

64,616 Da[Similar Products]

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

bifunctional purine biosynthesis protein PURH; AICARFT/IMPCHASE; OTTHUMP00000163981; OTTHUMP00000206773; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase

Bifunctional purine biosynthesis protein PURH

PURH??[Similar Products]

PUR9_HUMAN

This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria. [provided by RefSeq]

ATIC: Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. Defects in ATIC are the cause of AICAR transformylase/IMP cyclohydrolase deficiency (AICAR). A neurologically devastating inborn error of purine biosynthesis. Patients excrete massive amounts of AICA-riboside in the urine and accumulate AICA- ribotide and its derivatives in erythrocytes and fibroblasts. AICAR causes profound mental retardation, epilepsy, dysmorphic features and congenital blindness. Belongs to the PurH family.

Protein type: Nucleotide Metabolism - purine; Methyltransferase; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.3; EC 3.5.4.10; Hydrolase

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: mitochondrion; membrane; cytosol

Molecular Function: protein homodimerization activity; IMP cyclohydrolase activity; phosphoribosylaminoimidazolecarboxamide formyltransferase activity

Biological Process: purine ribonucleoside monophosphate biosynthetic process; organ regeneration; tetrahydrofolate biosynthetic process; response to inorganic substance; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; dihydrofolate metabolic process; nucleoside metabolic process; cerebellum development; cerebral cortex development; purine base metabolic process; 'de novo' IMP biosynthetic process

Disease: Aicar Transformylase/imp Cyclohydrolase Deficiency

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