Product Name
5-hydroxytryptamine receptor 3A (Htr3a), Recombinant Protein
Full Product Name
Recombinant Mouse 5-hydroxytryptamine receptor 3A (Htr3a)
Product Synonym Names
Recombinant 5-hydroxytryptamine receptor 3A (Htr3a); 5-hydroxytryptamine receptor 3A; 5-HT3-A; 5-HT3A; 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R Serotonin receptor 3A Serotonin-gated ion channel receptor
Product Gene Name
Htr3a recombinant protein
[Similar Products]
Product Synonym Gene Name
Htr3a; 5ht3, Htr3[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
24-487
Sequence
SRRRATQEDT TQPALLRLSD HLLANYKKGV RPVRDWRKPT TVSIDVIMYA ILNVDEKNQV LTTYIWYRQY WTDEFLQWTP EDFDNVTKLS IPTDSIWVPD ILINEFVDVG KSPNIPYVYV HHRGEVQNYK PLQLVTACSL DIYNFPFDVQ NCSLTFTSWL HTIQDINITL WRSPEEVRSD KSIFINQGEW ELLEVFPQFK EFSIDISNSY AEMKFYVIIR RRPLFYAVSL LLPSIFLMVV DIVGFCLPPD SGERVSFKIT LLLGYSVFLI IVSDTLPATI GTPLIGVYFV VCMALLVISL AETIFIVRLV HKQDLQRPVP DWLRHLVLDR IAWILCLGEQ PMAHRPPATF QANKTDDCSG SDLLPAMGNH CSHVGGPQDL EKTPRGRGSP LPPPREASLA VRGLLQELSS IRHFLEKRDE MREVARDWLR VGYVLDRLLF RIYLLAVLAY SITLVTLWSI WHYS
Chromosome Location
Chromosome: 9; NC_000075.6 (48899213..48911099, complement). Location: 9 A5.3; 9
3D Structure
ModBase 3D Structure for P23979
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Htr3a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Htr3a. It may not necessarily be applicable to this product.
NCBI Accession #
NP_038589.2
[Other Products]
NCBI GenBank Nucleotide #
NM_013561.2
[Other Products]
UniProt Primary Accession #
P23979
[Other Products]
UniProt Secondary Accession #
Q61225; Q61226[Other Products]
UniProt Related Accession #
P23979[Other Products]
Molecular Weight
56,056 Da[Similar Products]
NCBI Official Full Name
5-hydroxytryptamine receptor 3A isoform 1
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 3A
NCBI Official Symbol
Htr3a??[Similar Products]
NCBI Official Synonym Symbols
5-HT3
??[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 3A; 5-HT-3; 5-HT3A; 5-HT3R; 5-HT3-A; 5-HT3 receptor; serotonin receptor 3A; 5HT3 serotonin receptor; serotonin-gated ion channel receptor
UniProt Protein Name
5-hydroxytryptamine receptor 3A
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
Htr3a??[Similar Products]
UniProt Synonym Gene Names
5ht3; Htr3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R??[Similar Products]
UniProt Entry Name
5HT3A_MOUSE
UniProt Comments for Htr3a
5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Channel, ligand-gated; Transporter, ion channel; Membrane protein, multi-pass; Channel, cation
Cellular Component: postsynaptic membrane; membrane; cell soma; axon; cytoplasm; integral to membrane; plasma membrane; synapse; cell junction
Molecular Function: serotonin-activated cation-selective channel activity; voltage-gated potassium channel activity; serotonin binding; serotonin receptor activity; ligand-gated ion channel activity; extracellular ligand-gated ion channel activity
Biological Process: transport; ion transport; cation transport; serotonin receptor signaling pathway
Research Articles on Htr3a
1. Activation of central 5-HT(3) receptors is more effective in hypothermia induction due to marked decrease in thermogenesis and increase in heat loss. It switched metabolism to prevalent use of lipids as the main energetic substrate.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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