Full Product Name
Htr3a antibody - middle region
Product Gene Name
anti-HTR3A antibody
[Similar Products]
Product Synonym Gene Name
5-HT3; 5-HT3A; 5HT3; Htr3[Similar Products]
Antibody/Peptide Pairs
Htr3a peptide (MBS3227644) is used for blocking the activity of Htr3a antibody (MBS3202665)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: PATAIGTPLI GVYFVVCMAL LVISLAETIF IVQLVHKQDL QRPVPDWLRH
3D Structure
ModBase 3D Structure for P35563
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 93%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 79%
Immunogen
The immunogen is a synthetic peptide corresponding to a region of Rat
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-HTR3A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-HTR3A antibody
This is a rabbit polyclonal antibody against Htr3a. It was validated on Western Blot
Target Description: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Product Categories/Family for anti-HTR3A antibody
Polyclonal; Growth Factors & Hormones; Various;
Applications Tested/Suitable for anti-HTR3A antibody
Western Blot (WB)
Western Blot (WB) of anti-HTR3A antibody
WB Suggested Anti-Htr3a Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Rat Brain
NCBI/Uniprot data below describe general gene information for HTR3A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_077370
[Other Products]
NCBI GenBank Nucleotide #
NM_024394
[Other Products]
UniProt Primary Accession #
P35563
[Other Products]
UniProt Related Accession #
P35563[Other Products]
NCBI Official Full Name
5-hydroxytryptamine receptor 3A
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 3A
NCBI Official Symbol
Htr3a??[Similar Products]
NCBI Official Synonym Symbols
5HT3; Htr3; 5-HT3; 5-HT3A
??[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 3A
UniProt Protein Name
5-hydroxytryptamine receptor 3A
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
Htr3a??[Similar Products]
UniProt Synonym Gene Names
5ht3; Htr3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R??[Similar Products]
NCBI Summary for HTR3A
receptor for 5-hydroxytryptamine (serotonin); functions as a ligand-gated ion channel [RGD, Feb 2006]
UniProt Comments for HTR3A
5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel
Chromosomal Location of Human Ortholog: 8q23
Cellular Component: axon; cell junction; cell soma; cleavage furrow; cytoplasm; integral component of plasma membrane; plasma membrane; postsynaptic membrane; serotonin-activated cation-selective channel complex
Molecular Function: serotonin binding; serotonin-gated cation-selective channel activity
Biological Process: cation transmembrane transport; cellular response to growth factor stimulus; positive regulation of ion transmembrane transporter activity; response to cocaine; response to ethanol; signal transduction; synaptic transmission
Research Articles on HTR3A
1. Data support a functional role for serotonergic signaling in the mesolimbic pathway on motivated behavior, and demonstrate that 5-HT3 serotonin receptors differentially modulate food consumption in a region-dependent manner.
Precautions
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Disclaimer
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